000			01873nam a2200301Ia 4500
001			283244
003			OCoLC
005			20160527200609.0
008			061020s2007 flua b 001 0 eng
010			_a 2006035219
020			_a0849372720
035			_a(OCoLC)74459862
042			_apcc
049			_aPUXA
050	0	0	_aRA1220.3 _b.B64 2007
060	0	0	_a2007 F-245
060	1	0	_aQV 602 _bB671n 2007
082	0	0	_a615.9 _bB6718m2 _222
100	1		_aBoelsterli, Urs A. _2Local _963467
245	1	0	_aMechanistic toxicology _bthe molecular basis of how chemicals disrupt biological targets _cUrs A. Boelsterli.
250			_a2nd ed.
260			_aBoca Raton _bCRC Press _cc2007.
300			_a399 p. _bill. _c25 cm.
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.
650		0	_aMolecular toxicology. _2Local _9137566
856	4	2	_3Publisher description _uhttp://www.loc.gov/catdir/enhancements/fy0703/2006035219-d.html
999			_c204287 _d204287