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This volume contains data on multiple immunomodulators, many of which are also the products of hypothalamic brain cell neurosecretion. Interleukins (IL-1a, IL-1ß, IL-2, IL-4, IL-6, TNFa), immunophylin and ubiquitin as well as proline rich peptides, comprised of 10-15 amino acids are being produced in N. Supraopticus and N. Paraventricularis and then secreted into neurohypophysis. Along the neurosecretion of the mentioned cytokines, there are other immunomodulators, the primary structure of which had been completely deciphered such as: Immunophyllins, intracellular receptors of immunosuppressors FK506, cyclosporine A., rapamicin. They are peptidyl-prolyl-cis-trans-isomerases. There are novel immunological hypothalamic factors such as ubiquitin, macrophage migration inhibitory factor (MIF), as well as Thymosin ß 4(1-39). This data allowed us to propose the concept of neuroendocrine immune system of the brain.

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• Preface(p. v)
• Contributors(p. xi)
• Part 1 Neuro-Endocrine Immunoregulation
• 1 Brain Cytokines as Integrators of the Immune-Neuroendocrine Network(p. 1)
• 2 Neuropeptides in the Immune System: Mediators of Stress and Inflammation(p. 19)
• 3 Effects of the Immune System on Brain Neurochemistry(p. 37)
• 4 Age-Related Alterations in Autonomic Nervous System Innervation of Lymphoid Tissue(p. 61)
• 5 Drugs that Target Sympathetic-Immune Pathways for Treatment of Autoimmune Diseases(p. 83)
• 6 Neuro-Immune Associative Learning(p. 123)
• Part 2 The Brain's Immune System
• 7 The Brain Immune System: Chemistry and Biology of the Signal Molecules(p. 151)
• 8 The Dialect of Immune System in the CNS: The Nervous Tissue as an Immune Compartment for T Cells and Dendritic Cells(p. 197)
• 9 Immunoproteasome Activity in the Nervous System(p. 223)
• 10 Regulation of the Inflammatory Response in Brain(p. 235)
• 11 Evolutionary Origins of the Brain's Immune Privilege. Implications for Novel Therapeutic Approaches: Gene Therapy(p. 263)
• 12 Adenosine: An Endogenous Regulator of the Brain Immune System(p. 283)
• 13 Neuroimmune Cross Talk(p. 293)
• 14 Role of Glia in CNS Inflammation(p. 309)
• Part 3 Neuro-Immune Mechanisms of Brain Disease
• 15 Autoimmune Processes in the Central Nervous System(p. 331)
• 16 Experimental Autoimmune Encephalomyelitis(p. 355)
• 17 Immunological Aspects of Central Nervous System Demyelination(p. 379)
• 18 The Inflammatory Component of Neurodegenerative Diseases(p. 395)
• 19 Mechanisms of Inflammation in HIV-associated Dementia(p. 407)
• 20 Role of Poly(ADP-ribose) Polymerase in Brain Inflammation and Neuroinjury(p. 427)
• 21 Schizophrenia and Immune Responses(p. 467)
• Index(p. 489)