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This text aims to prepare readers for clinical practice by introducing them to the major issues in general and systematic pathology. It includes a review of normal anatomy and physiology in specific organ systems, and describes the causes, pathphysiology, pathology and clinical features of important diseases. It emphasizes the clinical relevance of pathology with end-of-chapter clinicopathologic reviews, and encourages learning with pedagogical tools such as opening outlines, learning objectives and key words and terms.