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Bioanalytical Chemistry provides a thorough introduction for students and practitioners with a broad range of backgrounds from chemistry to medicine. In so doing, it brings together many of the techniques commonly used by biochemists and molecular biologists. The text includes entire chapters on design and implementation of enzyme assays; mass spectrometry; and validation of new methods. Each chapter progresses from basic concepts to applications involving real samples, and ends with a set of problems, while an appendix contains selected answers. The authors have limited mathematical derivations to those that are essential for an understanding of each method and they include a list of suggested reading for further information. This textbook provides an ideal companion for students, researchers, and industrial scientists working in chemistry, biology, biochemistry, pharmacy, and medicine.

Tabla de contenidos provista por Syndetics

• Preface
• Acknowledgments
• 1 Spectroscopic Methods for Matrix Characterization
• 2 Enzymes
• 3 Quantitation of Enzymes and Their Substrates
• 4 Immobilized Enzymes
• 5 Antibodies
• 6 Quantitative Immunoassays with Labels
• 7 Biosensors
• 8 Directed Evolution for the Design of Macromolecular Bioassay Reagents
• 9 Principles of Electrophoresis
• 10 Applications of Zone Electrophoresis
• 11 Isoelectric Focusing
• 12 Capillary Electrophoresis
• 13 Centrifugation Methods
• 14 Chromatography of Biomolecules
• 15 Mass Spectrometry of Biomolecules
• 16 Validation of New Bioanalytical Methods
• Suggested References
• References
• Answers to Problems
• Index

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CHOICE Review

Mikkelsen (Univ. of Waterloo, Canada) and Corton (Univ. of Buenos Aires) comprehensively review the analytical methods used to characterize and quantify a wide variety of biological molecules and systems. Up-to-date and replete with references, the authors' survey of bioanalysis includes comparative details to assist readers in choosing among various methods available for a particular application. Each chapter is introduced with a short tutorial on the subject; the book provides information on all major methods of bioanalysis (electrophoresis, centrifugation, chromatography, spectroscopic methods, and enzyme assays) as well as more specialized methods (bioassays, biosensors, and immunoassays). It also includes full treatment of other analytical issues such as matrix effects and validation. This book will be a valuable resource for practitioners in the fields of biochemistry and molecular biology, especially those interested in new applications. It would also make an excellent graduate-level course resource, as it includes challenging end-of-chapter problems and additional, recommended reading. ^BSumming Up: Recommended. Graduate students through professionals. J. N. Granger Sweet Briar College

Notas de autor provistas por Syndetics

Susan R. Mikkelsen, PhD, is a professor in the Department of Chemistry at the University of Waterloo, Ontario, Canada.

Eduardo Cortón, PhD, is an adjunct professor in the Department of Biological Chemistry at the University of Buenos Aires, Argentina. He is also an investigator for the National Council of Scientific and Technical Research (CONICET) in Argentina.