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Providing a broad introduction to the growing field, this book explores the way in which peptides, proteins, nucleic acids and carbohydrates used therapeutically. With help of numerous illustrations, it covers both the compounds and how therapeutics exert their influence throuhg an understanding of biological processes.
* Includes the latest developments in the field
* Covers the various strategies behind the development and production of a range of key clinically useful compounds
* Focuses on the concepts and ideas of why compounds are developed as pharmaceuticals
* Provides many examples and problems
Invaluable to all students of chemistry, medicinal and pharmaceutical chemistry, pharmacy and pharmacology. Will also be of interest to researchers and professionals needing a concise, up-to-date account of this subject.

Tabla de contenidos provista por Syndetics

• Preface(p. ix)
• Abbreviations(p. xi)
• 1 Introduction(p. 1)
• 1.1 Overview(p. 1)
• 1.1.1 Endocrine disorders(p. 2)
• 1.1.2 Severe combined immunodeficiency disorders(p. 2)
• 1.2 Biomacromolecules in the Treatment of Human Disease(p. 4)
• 2 Endogenous Peptides and Proteins(p. 7)
• 2.1 Overview(p. 7)
• 2.2 Isolation from Natural Tissues and Fluids(p. 11)
• 2.3 Synthesis and Semi-Synthesis(p. 12)
• 2.3.1 Peptide synthesis(p. 12)
• 2.4 Gene Cloning(p. 26)
• 2.4.1 Growth hormone(p. 37)
• 2.5 Transgenic Procedures(p. 39)
• 2.6 Examples of Direct Replacement Strategy(p. 40)
• 2.6.1 Insulin(p. 40)
• 2.6.2 The fibrin and fibrinolytic cascades(p. 46)
• 3 Modification of Endogenous Peptides and Proteins(p. 55)
• 3.1 Overview(p. 55)
• 3.2 Peptide Mimetics(p. 56)
• 3.2.1 Mimetics based on luteinizing hormone-releasing hormone(p. 62)
• 3.2.2 Mimetics based on somatostatin(p. 64)
• 3.3 Chemical Modification of Proteins(p. 67)
• 3.3.1 Immunoassays(p. 69)
• 3.3.2 Modification with synthetic polymers(p. 72)
• 3.3.3 Modification of enzyme active sites(p. 74)
• 3.4 Protein Engineering(p. 75)
• 3.4.1 Site-directed mutagenesis(p. 76)
• 3.4.2 Chimeric toxins(p. 78)
• 3.4.3 Chimeric and humanized antibodies(p. 80)
• 3.4.4 The single-chain Fv(p. 85)
• 3.4.5 Phage display(p. 87)
• 4 The Immune System(p. 95)
• 4.1 Overview(p. 95)
• 4.2 The Antibody-Mediated Response(p. 95)
• 4.2.1 Polyclonal antibodies(p. 95)
• 4.2.2 Monoclonal antibodies(p. 99)
• 4.3 Vaccines(p. 107)
• 4.3.1 Hepatitis B vaccine(p. 108)
• 4.3.2 Approaches to an HIV vaccine(p. 110)
• 4.4 The Cell-Mediated Immune Response(p. 114)
• 4.4.1 Immunoenhancement(p. 119)
• 4.4.2 Immunosuppression(p. 119)
• 4.5 Cancer Immunotherapy(p. 124)
• 4.5.1 Antibody-mediated immunotherapy(p. 125)
• 4.5.2 T-cell-mediated immunotherapy(p. 128)
• 5 Oligonucleotides(p. 135)
• 5.1 Overview(p. 135)
• 5.2 Gene Therapy(p. 136)
• 5.2.1 Introduction(p. 136)
• 5.2.2 Ex vivo gene delivery(p. 138)
• 5.2.3 Clinical applications(p. 143)
• 5.3 Antisense Therapy(p. 151)
• 5.3.1 Introduction(p. 151)
• 5.3.2 Development of an antisense oligonucleotide(p. 154)
• 5.3.3 Clinical studies(p. 163)
• 5.4 Ribozymes(p. 164)
• 6 Oligosaccharides(p. 169)
• 6.1 Overview(p. 169)
• 6.2 Oligosaccharide Synthesis(p. 171)
• 6.3 Heparin(p. 178)
• 6.4 Glycoproteins(p. 179)
• 6.4.1 Blood group oligosaccharides(p. 180)
• 6.5 Polysaccharide Bacterial Vaccines(p. 182)
• 6.6 Approaches to Carbohydrate-Based Cancer Vaccines(p. 182)
• Appendix(p. 191)
• A.1 Amino Acids and Peptides(p. 191)
• A.1.1 Abbreviations and structural representations(p. 191)
• A.1.2 Secondary structures(p. 193)
• A.2 Oligonucleotides, DNA and RNA(p. 196)
• A.3 Carbohydrates(p. 199)
• Glossary(p. 203)
• Index(p. 215)

Notas de autor provistas por Syndetics

Christine Bladon is the author of Pharmaceutical Chemistry: Therapeutic Aspects of Biomacromolecules , published by Wiley.