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Covers the discovery, development, use and potential use, and regulation of plant-derived drugs. Describes ongoing research for prospective natural drugs with anticancer and anti-infective activities. Features some highly promising compounds, including artemisinin, camptothecin, forskolin, and taxol. Includes coverage of biologically active constituents of terrestrial and marine plants. Also addresses the effects of the destruction of rain forests on drug discovery.

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• Plant-Derived Natural Products in Drug Discovery and Development: An Overview
• Tropical Forest Biodiversity and the Potential for New Medicinal Plants
• Phytomedicines in Western Europe: Potential Impact on Herbal Medicine in the United States
• Biological and Chemical Diversity and the Search for New Pharmaceuticals and Other Bioactive Natural Products
• The Renaissance of Plant Research in the Pharmaceutical Industry
• Secondary Metabolism in Plant Tissue Cultures Transformed with Agrobacterium tumefaciens and Agrobacterium rhizogenes
• Role of Plants in the National Cancer Institute Drug Discovery and Development Program
• Logistics and Politics in Plant Drug Discovery: The Other End of the Spectrum
• Simple Bench-Top Bioassays (Brine Shrimp and Potato Discs) for the Discovery of Plant Antitumor Compounds: Review of Recent Progress
• Taxol, an Exciting Anticancer Drug from Taxus brevifolia: An Overview
• Camptothecin and Analogues: Synthesis, Biological In Vitro and In Vivo Activities, and Clinical Possibilities
• Antineoplastic Agents and Their Analogues from Chinese Traditional Medicine
• Novel Strategies for the Discovery of Plant-Derived Anticancer Agents
• Cancer Chemopreventive Agents: From Plant Materials to Clinical Intervention Trials
• National Cancer Institute Intramural Research on HIV-Inhibitory and Antitumor Plant Natural Products
• Discovery and Development of Novel Prototype Antibiotics for Opportunistic Infections Related to Acquired Immunodeficiency Syndrome
• Artemisia annua: From Weed to Respectable Antimalarial Plant
• Search for Molluscicidal and Larvicidal Agents from Plants
• Algal Secondary Metabolites and Their Pharmaceutical Potential
• Activation of the Isotypes of Protein Kinase C and Other Kinases by Phorbol Esters of Different Biological Activities
• Bioactive Organosulfur Compounds of Garlic and Garlic Products: Role in Reducing Blood Lipids
• Rohitukine and Forskolin: Second-Generation Immunomodulatory, Intraocular-Pressure-Lowering, and Cardiotonic Analogues

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CHOICE Review

The value of plant-derived natural products in the pharmaceutical industry is considerable: Approximately 25% of all new and refilled prescriptions dispensed from commercial pharmacies are obtained from plants. Thus, this recent symposium is of great importance to those studying plant chemistry, especially pharmaceutical chemists and organic chemists interested in total synthesis or modification of natural products. This book is organized into four sections: current role and importance of plant-derived natural products in drug discovery and development; anticancer and cancer chemo-preventive agents from plants; anti-infective and antimicrobial chemotherapeutic agents from plants; and promising plant-derived natural products with multiple biological activities. Of timely interest are papers addressing problems associated with the disappearing rain forests. Much discussion of antitumor and HIV-inhibiting plant products is given, including the recently approved anticancer agent taxol. Subject, author, and affiliation indexes are given as appendixes; references to works cited are listed at the end of each paper presented. Graduate; faculty. K. L. Marsi; California State University, Long Beach