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Known for generations as the most comprehensive foundational text on medical microbiology, Schaechter's Mechanisms of Microbial Disease delivers a thorough understanding of microbial agents and the pathophysiology of microbial diseases. This trusted text is universally praised for "telling the story of a pathogen" in an engaging way, facilitating learning and recall by emphasizing unifying principles and paradigms. Content is uniquely organized by microbial class and by organ system, making it equally at home in traditional and systems-based curricula.



This updated 6th Edition reflects the latest advances in the field, including significant enhancements to the coverage of serious threats to global health such as COVID-19, respiratory and childhood viruses, and sexually transmitted diseases. New illustrations and additional learning features further clarify concepts, reinforce understanding, and help users confidently prepare for board exams and beyond. Abundant full-color images clarify microbial concepts, structures, and processes in vivid detail. New Subject Review Tables broaden students' understanding of chapter content with additional context and detail. Paradigm boxes reinforce general principles through key examples. Case Studies with problem-solving questions, questions provide insight into clinical applications of microbiology, challenge students to apply what they've learned to common clinical scenarios. Key Concepts keep students focused on essential information. Suggested Readings guide students to relevant field research. Bolded Terms familiarize students with new or challenging terms. New content related to the COVID-19 pandemic concerning the virology, clinical features, treatment, and prevention of coronaviruses added to several relevant chapters prepares students for the clinical challenges ahead.

Tabla de contenidos provista por Syndetics

• Contributors(p. v)
• Preface(p. x)
• Acknowledgments(p. xii)
• Figure Credits(p. xiii)
• Part I Principles(p. 1)
• 1 Establishment of Infection(p. 3)
• 2 The Normal Microbiota(p. 11)
• 3 Biology of Infectious Agents(p. 18)
• 4 Genetic Approaches to Studying Bacterial Pathogenesis(p. 38)
• 5 Biological Basis for Antibacterial Action(p. 50)
• 6 Innate Immunity(p. 61)
• 7 Adaptive Immunity(p. 87)
• 8 The Parasite's Way of Life(p. 113)
• 9 Damage by Microbial Toxins(p. 123)
• Part II Infectious Agents(p. 135)
• 10 Introduction to the Pathogenic Bacteria(p. 137)
• 11 Staphylococci: Abscesses and Toxin-Mediated Diseases(p. 143)
• 12 Streptococci and Enterococci: "Strep Throat" and Beyond(p. 154)
• 13 Pneumococcus and Bacterial Pneumonia(p. 163)
• 14 Neisseriae: Gonococcus and Meningococcus(p. 172)
• 15 Bacteroides and Abscesses(p. 182)
• 16 Enteric Bacteria: Secretory Diarrhea(p. 188)
• 17 Invasive and Tissue-Damaging Enteric Bacterial Pathogens: Bloody Diarrhea and Dysentery(p. 197)
• 18 Pseudomonas aeruginosa. A Ubiquitous Opportunist(p. 211)
• 19 Bordetella and Whooping Cough(p. 220)
• 20 Clostridia: Diarrheal Disease, Tissue Infection, Botulism, and Tetanus(p. 227)
• 21 Legionella: Parasite of Amoebae and Macrophages(p. 233)
• 22 Helicobacter pylori: Persistent With a Potential for Menace(p. 240)
• 23 Mycobacteria: Tuberculosis and Leprosy(p. 248)
• 24 Syphilis: The Great Imitator(p. 259)
• 25 Borrelia burgdorferi and Lyme Disease(p. 265)
• 26 Bartonella Infections: Catscratch Disease, Bacillary Angiomatosis, and Other Diseases(p. 276)
• 27 Chlamydiae: Genital, Ocular, and Respiratory Pathogens(p. 281)
• 28 Rocky Mountain Sported Fever and Other Rickettsioses(p. 289)
• 29 Mycoplasma: Curiosity and Pathogen(p. 296)
• 30 Strategies to Combat Bacterial Infections(p. 302)
• 31 Biology of Viruses(p. 317)
• 32 Viral Infections and Exanthems of Early Childhood(p. 333)
• 33 Influenza and Its Viruses(p. 343)
• 34 Rhinoviruses, Adenoviruses, Corona viruses: The Common Cold and Beyond(p. 351)
• 35 Viral Agents of the GI Tract(p. 362)
• 36 Viral Hepatitis(p. 371)
• 37 Rabies(p. 382)
• 38 Arthropod-Borne Viruses(p. 389)
• 39 Human Papillomaviruses and Warts(p. 397)
• 40 Alphaherpesviruses: Herpes Simplex Viruses and Varicella-Zoster Virus(p. 405)
• 41 Beta- and Gammaherpesviruses: Cytomegalovirus and Epstein-Barr Virus(p. 414)
• 42 The Human Retroviruses: AIDS and Other Diseases(p. 426)
• 43 Antiviral Treatment Strategies(p. 439)
• 44 Vaccines and Antisera for the Prevention and Treatment of Infectious Diseases(p. 451)
• 45 Introduction to the Fungi and Mycoses(p. 459)
• 46 Endemic Mycoses(p. 463)
• 47 Opportunistic Fungal Infections(p. 470)
• 48 Subcutaneous, Cutaneous, and Superficial Mycoses(p. 478)
• 49 Antifungal Agents(p. 483)
• 50 Introduction to Parasitology(p. 488)
• 51 Blood and Tissue Protozoa(p. 497)
• 52 Intestinal and Vaginal Protozoa(p. 512)
• 53 Intestinal Helminths(p. 521)
• 54 Tissue and Blood Helminths(p. 531)
• 55 Prion Diseases(p. 544)
• 56 Surveillance for and Response to the Emergence of Threatening Pathogens(p. 551)
• Part III Pathophysiology of Infectious Diseases(p. 565)
• 57 Diagnostic Principles(p. 567)
• 58 Principles of Epidemiology(p. 579)
• 59 Digestive System Infections(p. 587)
• 60 Infections of the Central Nervous System(p. 603)
• 61 Respiratory System Infections(p. 619)
• 62 Urinary Tract Infections(p. 632)
• 63 Infections of the Skin and Soft Tissue(p. 642)
• 64 Infections of the Bones, Joints, and Muscles(p. 653)
• 65 Sepsis(p. 662)
• 66 Intravascular Infection(p. 671)
• 67 Head and Neck Infections(p. 683)
• 68 Sexually Transmitted Diseases(p. 690)
• 69 Infections of the Immunocompromised Patient(p. 697)
• 70 Acquired Immunodeficiency Syndrome(p. 703)
• 71 Congenital and Perinatal Infections(p. 715)
• 12 Zoonoses(p. 722)
• 73 Fever: A Clinical Sign of Infection(p. 732)
• 74 Health Care-Associated Infections(p. 739)
• 75 Foodborne Diseases(p. 746)
• Appendix(p. 755)
• Glossary(p. 784)
• Index(p. 817)