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The bestselling introduction to bioinformatics and functional genomics-now in an updated edition

Widely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded Second Edition, it continues to be the go-to source for students and professionals involved in biomedical research.

This edition provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:

Several fundamentally important proteins, such as globins, histones, insulin, and albumins, are included to better show how to apply bioinformatics tools to basic biological questions. A completely updated companion web site , which will be updated as new information becomes available - visit www.wiley.com/go/pevsnerbioinformatics Descriptions of genome sequencing projects spanning the tree of life. A stronger focus on how bioinformatics tools are used to understand human disease.

The book is complemented by lavish illustrations and more than 500 figures and tables-fifty of which are entirely new to this edition. Each chapter includes a Problem Set, Pitfalls, Boxes explaining key techniques and mathematics/statistics principles, Summary, Recommended Reading, and a list of freely available software. Readers may visit a related Web page for supplemental information at www.wiley.com/go/pevsnerbioinformatics.

Bioinformatics and Functional Genomics, Second Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.

Praise for the first edition:

"...ideal both for biologists who want to master the application of bioinformatics to real-world problems and for computer scientists who need to understand the biological questions that motivate algorithms." Quarterly Review of Biology

"... an excellent textbook for graduate students and upper level undergraduate students." Annals of Biomedical Engineering

"...highly recommended for academic and medical libraries, and for researchers as an introduction and reference..." E-Streams

Tabla de contenidos provista por Syndetics

• Preface to the Second Edition
• Preface to the First Edition
• Foreword
• Part I Analyzing Dna, Rna, And Protein Sequences In Databases
• 1 Introduction
• 2 Access to Sequence Data and Literature Information
• 3 Pairwise Sequence Alignment
• 4 Basic Local Alignment Search Tool (BLAST
• 5 Advanced Database Searching
• 6 Multiple Sequence Alignment
• 7 Molecular Phylogeny and Evolution
• Part II Genomewide Analysis Of Rna And Protein
• 8 Bioinformatic Approaches to Ribonucleic Acid (RNA
• 9 Gene Expression: Microarray Data Analysis
• 10 Protein Analysis and Proteomics
• 11 Protein Structure
• 12 Functional Genomics
• Part III Genome Analysis
• 13 Completed Genomes
• 14 Completed Genomes: Viruses
• 15 Completed Genomes: Bacteria and Archaea
• 16 The Eukaryotic Chromosome
• 17 Eukaryotic Genomes: Fungi
• 18 Eukaryotic Genomes: From Parasites to Primates
• 19 Human Genome
• 20 Human Disease
• Glossary
• Answers to Self-Test Quizzes
• Author Index
• Subject Index

Reseñas proporcionadas por Syndetics

CHOICE Review

Pevsner (Johns Hopkins School of Medicine) provides an integrative approach to understanding theory and practice of the field of bioinformatics, from sequence analysis, gene expression, microarrays, and proteomics to phylogenetics and genome studies. He shows how bioinformatics applies to biological questions at different levels, through disease. He combines theoretical context with practical applications, emphasizing skills such as analyzing genes and proteins, creating phylogenetic trees, extracting data, and identifying genes and proteins implicated in disease. The book provides a systematic three-part format beginning with the analysis of biological sequence data, continuing with functional genomics (microarrays, proteomics), and concluding with coverage of genomes via the tree of life. The human genome chapter concludes with bioinformatics advances toward human disease. Without using too much technical detail, Pevsner has created an intriguing work targeted toward biologists wanting to solve problems. His book provides a compendium of many biological insights and breakthroughs and will be a useful resource for computational scientists who want to understand the biological problems attacked by bioinformatics. Pevsner assumes no computational background, so the book is appropriate for every level of study. ^BSumming Up: Highly recommended. All levels. J. Kushner James Madison University