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BRS Biochemistry, Molecular Biology, and Genetics is an excellent aid for USMLE Step 1 preparation and for coursework in biochemistry, molecular biology, and genetics. Fully updated for its sixth edition, chapters are written in an outline format and include pedagogical features such as bolded key words, figures, tables, algorithms, and highlighted clinical correlates. USMLE-style questions and answers follow each chapter and a comprehensive exam appears at the end of the book.

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• Preface and Acknowledgements(p. v)
• How to Use this Book(p. vi)
• 1 Fuel Metabolism and Nutrition: Basic Principles(p. 1)
• I Metabolic Fuels and Dietary Components(p. 1)
• II The Fed or Absorptive State(p. 5)
• III Fasting(p. 7)
• IV Prolonged Fasting (Starvation)(p. 9)
• Review Test(p. 11)
• 2 Basic Aspects of Biochemistry: Organic Chemistry, Acid-Base Chemistry, Amino Acids, Protein Structure and Function, and Enzyme Kinetics(p. 19)
• I A Brief Review of Organic Chemistry(p. 19)
• II Acids, Bases, and Buffers(p. 20)
• III Amino Acids and Peptide Bonds(p. 22)
• IV Protein Structure(p. 25)
• V Enzymes(p. 34)
• Review Test(p. 39)
• 3 Gene Expression (Transcription), Synthesis of Proteins (Translation), and Regulation of Gene Expression(p. 51)
• I Nucleic Acid Structure(p. 52)
• II Synthesis of DNA (Replication)(p. 58)
• III Synthesis of RNA (Transcription)(p. 66)
• IV Protein Synthesis (Translation of mRNA)(p. 70)
• V Regulation of Protein Synthesis(p. 77)
• VI Recombinant DNA and Medicine(p. 86)
• Review Test(p. 95)
• 4 Cell Biology, Signal Transduction, and the Molecular Biology of Cancer(p. 109)
• I Compartmentation in Cells; Cell Biology and Biochemistry(p. 110)
• II Cell Signaling by Chemical Messengers(p. 116)
• III The Molecular Biology of Cancer(p. 125)
• IV Cancer and Apoptosis(p. 131)
• V Cancer Requires Multiple Mutations(p. 133)
• VI Viruses and Human Cancer(p. 133)
• Review Test(p. 134)
• 5 Generation of ATP From Metabolic Fuels and Oxygen Toxicity(p. 145)
• I Bioenergetics(p. 145)
• II Properties of Adenosine Triphosphate(p. 147)
• III Electron Carriers and Vitamins(p. 148)
• IV TCA Cycle(p. 154)
• V Electron Transport Chain and Oxidative Phosphorylation(p. 159)
• VI Oxygen Toxicity and Free-Radical Injury(p. 164)
• Review Test(p. 170)
• 6 Carbohydrate Metabolism(p. 181)
• I Carbohydrate Structure(p. 181)
• II Proteoglycans, Glycoproteins, and Glycolipids(p. 185)
• III Digestion of Carbohydrates(p. 188)
• IV Glycogen Structure and Metabolism(p. 190)
• V Glycolysis(p. 197)
• VI Gluconeogenesis(p. 204)
• VII Fructose and Galactose Metabolism(p. 209)
• VIII Pentose Phosphate Pathway(p. 212)
• IX Maintenance of Blood Glucose Levels(p. 215)
• Review Test(p. 220)
• 7 Lipid and Ethanol Metabolism(p. 230)
• I Lipid Structure(p. 232)
• II Membranes(p. 234)
• III Digestion of Dietary Triacylglycerol(p. 235)
• IV Fatty Acid and Triacylglycerol Synthesis(p. 237)
• V Formation of Triacylglycerol Scores in Adipose Tissue(p. 242)
• VI Cholesterol and Bile Salt Metabolism(p. 243)
• VII Blood Lipoproteins(p. 246)
• VIII Fate of Adipose Triacylglycerols(p. 251)
• IX Fatty Acid Oxidation(p. 252)
• X Ketone Body Synthesis and Utilization(p. 257)
• XI Phospholipid and Sphingolipid Metabolism(p. 259)
• XII Metabolism of the Eicosanoids(p. 262)
• XIII Ethanol Metabolism(p. 264)
• Review Test(p. 268)
• 8 Nitrogen Metabolism-Amino Acids, Purines, Pyrimidines, and Products Derived from Amino Acids(p. 279)
• I Protein Digestion and Amino Acid Absorption(p. 280)
• II Addition and Removal of Amino Acid Nitrogen(p. 282)
• III Urea Cycle(p. 284)
• IV Synthesis and Degradation of Amino Acids(p. 286)
• V Interrelationships of Various Tissues in Amino Acid Metabolism(p. 294)
• VI Tetrahydrofolate, Vitamin B 12 , and S-Adenosylmethionine(p. 298)
• VII Special Products Derived from Amino Acids(p. 302)
• Review Test(p. 313)
• 9 Molecular Endocrinology and an Overview of Tissue Metabolism(p. 325)
• I Synthesis of Hormones(p. 325)
• II General Mechanisms of Hormone Action (Only a Summary is Provided here as this has Already Been Covered in Chapter 4.)(p. 329)
• III Regulation of Hormone Levels(p. 329)
• IV Actions of Specific Hormones(p. 330)
• V Biochemical Functions of Tissues(p. 339)
• Review Test(p. 350)
• 10 Human Genetics-An Introduction(p. 359)
• I Mendelian Inheritance Patterns(p. 360)
• II Genes(p. 360)
• III Mutations(p. 361)
• IV Inheritance Patterns(p. 362)
• V A Summary of Inheritance Patterns is given in Table 10.1(p. 367)
• VI Cytogenetics(p. 367)
• VII Population Genetics(p. 372)
• VIII Multifactorial Diseases (Complex Traits)(p. 372)
• IX Triplet Repeal Expansions(p. 373)
• X Imprinting(p. 374)
• XI The Genetics of Tumor Suppressors(p. 376)
• Review Test(p. 378)
• Comprehensive Examination(p. 389)
• Index(p. 431)