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Fully updated and expanded-a solid foundation for understanding experimental enzymology.
This practical, up-to-date survey is designed for a broad spectrum of biological and chemical scientists who are beginning to delve into modern enzymology. Enzymes, Second Edition explains the structural complexities of proteins and enzymes and the mechanisms by which enzymes perform their catalytic functions. The book provides illustrative examples from the contemporary literature to guide the reader through concepts and data analysis procedures. Clear, well-written descriptions simplify the complex mathematical treatment of enzyme kinetic data, and numerous citations at the end of each chapter enable the reader to access the primary literature and more in-depth treatments of specific topics.
This Second Edition of Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis features refined and expanded coverage of many concepts, while retaining the introductory nature of the book. Important new features include:
* A new chapter on protein-ligand binding equilibria
* Expanded coverage of chemical mechanisms in enzyme catalysis and experimental measurements of enzyme activity
* Updated and refined discussions of enzyme inhibitors and multiple substrate reactions
* Coverage of current practical applications to the study of enzymology
Supplemented with appendices providing contact information for suppliers of reagents and equipment for enzyme studies, as well as a survey of useful Internet sites and computer software for enzymatic data analysis, Enzymes, Second Edition is the ultimate practical guide for scientists and students in biochemical, pharmaceutical, biotechnical, medicinal, and agricultural/food-related research.

Tabla de contenidos provista por Syndetics

• A Brief History of Enzymology
• Chemical Bonds and Reactions in Biochemistry
• Structural Components of Enzymes
• Protein-Ligand Binding Equilibria
• Kinetics of Single-Substrate Enzyme Reactions
• Chemical Mechanisms in Enzyme Catalysis
• Experimental Measures of Enzyme Activity
• Reversible Inhibitors
• Tight Binding Inhibitors
• Time-Dependent Inhibition
• Enzyme Reactions with Multiple Substrates
• Cooperativity in Enzyme Catalysis
• Appendices
• Index

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CHOICE Review

Copeland's new edition (1st ed., 1996) is a welcome volume for any reader concerned with this important class of biological macromolecules. The book is interesting, informative, and very readable. Though the focus is on enzymes, there is a great deal of information on protein structure, in general, and on receptor-ligand binding. Theoretical discussions of energetics and kinetics are well balanced with practical considerations such as sources of errors and factors affecting the measurement of reaction velocities. Clear examples that bring home important points are sprinkled throughout, and each chapter is well referenced. The book begins with reviews of fundamental concepts of chemistry and the nature of proteins before progressing to a fine kinetic discussion that includes all the appropriate cautions for doing kinetic experiments well and interpreting their results correctly. The last chapters take the work to a level of sophistication that is often omitted, analyzing more complex modes of inhibition and introducing structure-activity relationship studies. A valuable acquisition for academic libraries. Upper-division undergraduates and above. J. A. Kelly; University of Connecticut

Notas de autor provistas por Syndetics

Robert A. Copeland is Director of Chemical Enzymology at the DuPont Pharmaceuticals Company and Adjunct Professor of Biochemistry and Biophysics at the University of Pennsylvania School of Medicine.