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The long-awaited second edition of an authoritative reference on electrophysiologic vision testing, including detailed information on techniques and problems, basic physiology and anatomy, theoretical concepts, and clinical findings; with extensive new material.

This authoritative text is the only comprehensive reference available on electrophysiologic vision testing, offering both practical information on techniques and problems as well as basic physiology and anatomy, theoretical concepts, and clinical correlations. The second edition, of the widely used text, offers extensive new material and updated information: 65 of the 84 chapters are completely new, with the changes reflecting recent advances in the field. The book will continue to be an essential resource for practitioners and scholars from a range of disciplines within vision science.

The contributions not only cover new information-important material that is likely to become more important in the next decade-but also offer a long-range perspective on the field and its remarkable development in the last century. After discussing the history and background of clinical electrophysiology, the book introduces the anatomy of the retina and principles of cell biology in the visual pathways at the molecular, physiological, and biochemical levels. It relates these new findings to the techniques and interpretations of clinical tests, including the electro-oculogram (EOG), electroretinogram (ERG), and visual evoked potentials (VEP), which are discussed in detail, as are equipment, data acquisition and analysis, principles and protocols for clinical testing, diseases and dysfunction, and animal testing. Notable additions for this edition include chapters on the origin of electroretinogram waveforms, multifocal techniques, testing in standard laboratory animals, recent advances in analysis of abnormalities in disease, and the applications of these techniques to the study of genetic abnormalities.

Tabla de contenidos provista por Syndetics

• Part I History and background to modern testing
• 1 History of the Electroretinogram
• 2 History of Electro-Oculography
• 3 History of Visual Evoked Cortical Testing
• Part II Anatomy of the Retina, Principles of Cell Biology in the Visual Pathways: Functional, Physiological, Biochemical, Molecular Biological
• 4 The Photoreceptor-Retinal Pigment Epithelium Interface
• 5 Membrane Mechanisms of the Retinal Pigment Epitelium
• 6 Functional Organization of the Retina
• 7 Synaptic Transmission: Sensitivity Control Mechanisms
• 8 Phototransduction and Photoreceptor Physiology
• 9 Structure and Function of Retinal Synapses: Role of Cell Adhesion Molecules and Extracellular Matrix
• 10 Central Disorders of Vision in Humans
• Part III Origins of Slow Electrophysiological Components
• 11 The Electro-oculogram
• 12 Orgins of the Electroretinogram
• 13 The Origin of the Pattern Electroretinogram (PERG)
• 14 The Multifocal ERG and VEP Techniques
• 15 Origin of the VEP Potentials
• Part IV Equipment
• 16 Data Acquisition Systems for Electrodiagnostic Testing
• 17 Electrodes for Visual Testing
• 18 Amplifiers and Special-Purpose Data Acquisitions Systems
• 19 Stimulus Devices, Calibration and Measurement of Light
• Part V Data Acquisition
• 20.1 Introduction to the ISCEV Standards
• 20.2 EOG Standard
• 20.3 Standard for Clinical Electroretinography
• 20.4 Standard for Pattern Electroretinography
• 20.5 Visual Evoked Potentials Standard
• 20.6 Guidelines for Basic Multifocal Electroretinography (mfERG)
• 21 Multifocal Techniques
• 22 The Pattern Electroretinogram
• 23 Assessing Infant Acuity, Fusion, and Stereopsis with Visual Evoked Potential
• 24 Aging and Pattern Visual Evoked Cortical Potential
• 25 Aberrant Albino and Achiasmat Visual Pathways: Noninvasive Electrophysiological Assessment
• 26 Clinical psychophysical techniques
• 27 Measurement of Contrast Sensitivity
• 28 Suppressive Rod-Cone Interaction
• 29 The Use of Fluorescein Angiography as an Adjunct to Electrophysiological Testing
• Part VI Data Analysis
• 30 Experimental Design and Data Analyses in Vision Function Testing
• 31 Analytical Techniques
• 32 Reverse Correlation Methods
• 33 Stimulus-Response Functions for the Scotopic b-Wave
• 34 Kernel Analysis
• 35 Measuring the Health of the Human Photoreceptors with the Leading Edge of the a-Wave
• Part VII Principles of Clinical Testing
• 36 Localizing Lesions in the Visual System
• 37 Paired-Flash ERG Analysis of Rod Phototransduction and Adaptation
• 38 Hyperabnormal (Supranormal) Electroretinographic Responses
• 39 Technical Issues in Evaluating Patients in Therapeutic Trials
• Part VIII Other Protocols for Recording of ERG and Slower Potentials, Technical Issues, and Auxiliary Testing Techniques
• 40 Early Receptor Potential
• 41 Nonphotic Standing Potential Responses: Hyperosmolarity, Bicarbonate, and Diamox Responses
• 42 Direct Current (DC) Electroretinogram
• 43 The Oscillatory Potentials of the Electroretinogram
• 44 Flicker Electroretinography
• 45 Chromatic Recordings of Electroretinograms
• 46 Adaptation Effects on the Electroretinogram
• 47 Clinical Electrophysiological and Psychophysical Investigations into Color Defects
• 48 Causes and Cures of Artifacts
• Part IX Principles of Clinical Testing and Evaluation of Visual Dysfunction from Developmental, Toxic, and Acquired Causes
• 49 Testing Levels of the Visual System
• 50 Effects of High Myopia on the Electroretinogram
• 51 Electrodiagnostic Testing in Malingering and Hysteria
• 52 Developmental Amblyopia
• 53 Visually Evoked Potentials in Cortical Blindness
• 54 Drug Side Effects and Toxicology of the Visual System
• 55 Mitochondrial Diseases
• Part X Evaluation of Vascular Diseases, Inflammatory States, and Tumors
• 56 Diseases of the Middle Retina: Venous and Arterial Occlusions
• 57 Acute Disorders of the Outer Retina, Pigment Epithelium and Choroid
• 58 Autoimmune retinopathy, CAR and MAR Syndromes
• 59 Ischemic Optic Neuropathy
• Part XI Clinical Descriptions: Retinal Pigment Epithelium Diseases
• 60 Gyrate Atrophy of the Choroid and Retina
• 61 Dominant Drusen
• 62 Stargardt Disease
• 63 Bietti's Crystalline Dystrophy of Cornea and Retina
• 64 Leber Congenital Amaurosis
• 65 Pattern Dystrophies
• 66 Best Vitelliform Macular Dystrophy
• 67 Sorsby's Fundus Dystrophy
• Part XII Diseases of the Outer Retina
• 68 Choroideremia
• 69 Retinitis Pigmentosa
• 70 Cone Dystrophies and Degenerations
• 71 Vitamin A Deficiency
• Part XIII Diseases of the Midretina (Including Negative Waveform Diseases)
• 72 Differential Diagnosis of the Electronegative Electroretinogram
• 73 Juvenile X-Linked Retinoschisis
• 74 Congenital Stationary Night Blindness
• 75 Quinine Retinopathy
• Part XIV Optic Nerve and Central Nervous System Dysfunction
• 76 Leber's Hereditary Optic Neuropathy
• 77 The Pattern Electroretinogram in Glaucoma and Ocular Hypertension
• 78 Chiasmal and Retrochiasmal Lesions
• 79 Optic Nerve and Central Nervous Dysfunctions: Parkinson's Disease and Multiple Sclerosis
• 80 Diseases of Fatty Acid Storage and Metabolism: Neuronal Ceroid Lipofuscinoses and the Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency
• Part XV Animal Testing
• 81 Evaluating Retinal Function in the Mouse Retina with the Electroretinogram
• 82 ERGs of Dog and Chicken
• 83 ERG Testing in Larger Animals
• 84 Visual Evoked Potentials in Animals

Notas de autor provistas por Syndetics

John R. Heckenlively is Paul R. Lichter Professor of Ophthalmic Genetics and Professor of Ophthalmology and Visual Sciences at the University of Michigan Kellogg Eye Center in Ann Arbor.

Geoffrey B. Arden is Professor of Ophthalmology and Visual Sciences, Henry Wellcome Research Laboratories, City University, Northampton Square, London.