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Adopting a unique approach, this novel textbook integrates science and business for an inside view on the biotech industry. Peering behind the scenes, it provides a thorough analysis of the foundations of the present day industry for students and professionals alike: its history, its tools and processes, its markets and products. The authors, themselves close witnesses of the emergence of modern biotechnology from its very beginnings in the 1980s, clearly separate facts from fiction, looking behind the exaggerated claims made by start-up companies trying to attract investors. Essential reading for every student and junior researcher looking for a career in the biotech sector.

Tabla de contenidos provista por Syndetics

• Classical Biotechnology
• The early period till 1850
• The period from 1850 to 1890
• The period from 1890 to 1950
• From 1950 onwards
• The changing focus in biotechnology in the early 1980s -
• The OTA report
• The Basics Of New Biotechnology
• Recombinant technologies
• Molecular biotechnology
• Industrial (White) Biotechnology
• Raw materials, resources, tools
• Biocatalysis
• Biorefineries
• Biofuels, energy, biogas
• Bulk chemicals, products for polymers, pharmaceuticals, food and feed
• Biopolymers
• Fine chemicals - chiral synthons, enzymes, nutraceuticals
• Food processing and products
• Environmental processes
• Pharmaceutical (Red) Biotechnology
• Drug targeting, discovery strategies and development
• Rational, or structure based strategies
• The case of Epothilone
• Pharmaceuticals production
• Antibiotics and steroids
• Recombinant proteins
• Cell systems
• Medicinal techniques, diagnostics
• Business: companies and economic aspects
• Political and ethical aspects
• Agricultural (Green) Biotechnology
• Political, ethical and biosafety aspects
• Consumer acceptance and public perception
• Crop protection
• Products of primary metabolism: carbohydrates, proteins, lipids, biopolymers
• Products of secondary metabolism: pharmaceuticals, vitamins, flavors, fragrances
• Resistance to fungi and viruses
• Resistance to herbicides and drought
• Improvements in plant quality and photosynthesis efficiency
• Economic aspects

Reseñas proporcionadas por Syndetics

CHOICE Review

This is yet another retelling of the history and application of biotechnology, from its inception when humans first fermented grains and produced leavened breads up through today's latest diagnostics and drugs and the redesign of proteins and organisms. Among the many books on this topic, it is perhaps one of the best referenced, but it does not contain much new information, and the text is not presented in a better format than that of other works. Buchholz (Technical Univ. of Braunschweig, Germany) and Collins (Helmholtz Centre for Infection Biology, Braunschweig) focus on the individuals who drove the science and include many players who perhaps have not received the recognition they deserve for their contributions. The book is fairly comprehensive; besides covering discoveries, it discusses applications, government oversight, and public opinion on more controversial issues. However, some topics are ignored, such as the industrial use of enzymes in organic solvents, and others are weighted too heavily. There was no need to rehash Michaelis-Menten kinetics in two pages or publish the picture of every scientist mentioned in the text. The tone of the book clearly gears the work toward practitioners; it might not be particularly useful for beginners. Summing Up: Recommended. Graduate students and above. J. M. Tomich Kansas State University

Notas de autor provistas por Syndetics

Born in 1941, Klaus Buchholz studied chemistry at the universities of Saarbrücken und Heidelberg (Germany), graduating in 1967. In 1969 he received his PhD from the Technical University of Munich, after which he worked as a researcher with a group on biocatalysis at Dechema e.V. in Frankfurt/Main. In 1981 he received his Habilitation at the Technical University of Braunschweig, where he then became department head at the Institute for Agricultural Technology and Sugar Industry. In 1991 he became Professor at the Institute for Chemical Engineering. His main research areas include biocatalysts, enzymatic synthesis of carbohydrates, and environmental biotechnology. He is also the author of a
well-known textbook on biocatalysts and an advisory board member of several journals.

Born in 1945, John Collins studied Microbiology (B.Sc.) at University College, London University, and a doctorate (Ph.D.; 1971) at the University of Leicester, UK. Postdoctoral work was carried out at UCSD, La Jolla 1971-4 with Don Helinski at the time DNA cloning was developed in collaboration with the Cohen and Boyer labs.
He brought this technology to the University of Copenhagen, developing gene cloning methods to isolate and study bacterial and eukaryotic genes and how they are regulated. In 1975 he joined the German National Center for Biotechnological Research (GBF; now HZI) in Braunschweig initiating some of the first experiments to apply gene technology to biotechnological projects (Penicillin acylase, interferon ß; Cytomegalovirus; mutein design of protease inhibitors). In 1987 he accepted a joint appointment as section Head for Cell Biology and Genetics at the GBF and as Professor at the Technical University of Braunschweig. He has worked as international adviser to a number of governments and institutes and lectures on biotechnology, intellectual property, genetics and evolution. He is an elected EMBO (European Molecular Biology Organisation) member and was a founding member of the Human Genome Organistion (HUGO). In 1997 he founded a Biotech Company which was acquired by a Californian Company in 2002. His current work is directed at the development of Inhibitors
of Hepatitis C virus using combinatorial biology as well as trying to explain the impact of scientific developments to the informed public.