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Today's chemists need to know how hazardous the chemicals they work with are, and they want to understand the relationship between chemical and structural properties and toxicity. At the same time, modern society requires that chemists have this kowledge, as legislation makes the producers/users of chemicals responsible for any adverse effects. The book deals with the effects on both man and ecosystems. It stresses especially on the relationship between chemical structure and chemical properties/toxic effects and metabolic conversions.
This is not just another book on toxicology. What makes this book special is that it is written from a chemical point of view. This textbook applies the basic principles of reactivity and reaction possibilities of organic compounds to metabolic reactions and living systems.

Tabla de contenidos provista por Syndetics

• Chemicals and Society
• Organic Compounds
• Chemical Properties
• The Chemicals of Nature
• Toxicological Concepts
• Uptake, Distribution and Elimination of Chemicals
• Metabolism of Exogenous Compounds in Mammals
• The Principal Conversions
• Metabolism of Exogenous Compounds in Mammals
• Conversions and Transformations in the Environment
• Toxic Effects of Chemicals
• The Molecular Basis for Genotoxicity and Carcinogenicity
• Environmental Effects of Chemicals
• The Assessment of Organic Structures
• Glossary
• Index

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CHOICE Review

This new edition (1st ed., 1999) provides more than 350 pages of well-written, comprehensive, up-to-date information on human and environmental toxicity of both man-made and naturally synthesized organic and inorganic chemicals. If the reader is not already fairly familiar with the concept of an electrophile and a nucleophile, then this book would be very heavy going. Sterner (Lund Univ., Sweden) unfortunately uses the word "chemical" to mean "man-made chemical." He states: "Today, we are well aware that most tumors that afflict humans are caused by chemicals ..."; this is certainly correct if the meaning of chemicals is the broad meaning espoused by chemists. If the author means that most human tumors are caused by exposure to man-made chemicals, then he should at least provide a credible reference. The total lack of any literature references is one of the few drawbacks of this otherwise excellent tome. This reviewer learned about such diverse topics as the amazing chlorinated organics produced by fungi and the interesting human metabolism of asparagus. Detailed chapter subsection headings and a comprehensive index make this a usable reference book. Summing Up: Recommended. Upper-division undergraduates and above. D. H. Stedman University of Denver