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Evolution in health and disease edited by Stephen C. Stearns.

Colaborador(es): Detalles de publicación: Oxford New York Oxford University Press 1999.Descripción: xv, 328 p. ill., map 26 cmISBN:
  • 0198501102 (hbk)
  • 0198504454 (pbk)
Otro título:
  • Evolution in health & disease [Título de cubierta]
Tema(s): Clasificación CDD:
  • 616.042 E938 21
Clasificación LoC:
  • RB155 .E96 1999
Clasificación NLM:
  • QH 366.2
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Descripciones mejoradas de Syndetics:

For most of our history, humans lived in small hunter-gatherer groups whose diets, living conditions, and environmental pressures were very different from what most humans face today. The result is that the evolutionary adaptations which proved beneficial in our past may prove less so now. This fascinating book explores the implications of human evolutionary history for human health and medicine. The topics include the evolution of antibiotic resistance, the evolution of pathogen virulence, the evolution of aging, the design of vaccines, and population- and genotype-specific reactions to drugs and susceptibility to disease. The book also discusses new insights into mother-offspring conflict during pregnancy, menstruation, menopause, child abuse, homicide, depression, schizophrenia, and many chronic degenerative diseases, such as cancer and osteoporosis. Written by leading experts in evolutionary medicine and addressed to medical students and researchers and evolutionary biologists, the book describes the state of the art and provides clear access to the primary literature. It also provides compelling arguments for why the tools evolutionary biology belong in every doctor's tool-kit.

Based on a conference held in Sion, Switzerland, 6-12 Apr. 1997.

Includes bibliographical references (p. 273-316) and index.

Tabla de contenidos provista por Syndetics

  • List of Contributors
  • Part I Introduction
  • 1 Introducing evolutionary thinking
  • 2 Research designs that address evolutionary questions about medical disorders
  • Part II Human history and human genes
  • 3 The history and geography of human genetic diversity
  • 4 Medically relevant genetic variation of drug effects, Urs
  • 5 Genetic variation and human disease: The role of natural selection
  • 6 Human genetic variation and its impact on public health and medicine
  • Part III Natural selection, conflicts, and constraints
  • 7 Genetic conflicts of pregnancy and childhood
  • 8 Human evolution and disease: putting the Stone Age in perspective
  • 9 Pathogen-driven sexual selection and the evolution of health
  • 10 Evolutionary interpretations of the diversity of reproductive health and disease
  • Part IV Pathogens, drugs and virulence
  • 11 The population biology of anti-infective chemotherapy and the evolution of drug resistance: more questions than answers
  • 12 Development and use of vaccines against evolving pathogens: vaccine design
  • 13 Evolution of infectious diseases: the impact of vaccines, drugs and social factors
  • 14 The evolution and expression of parasite virulence
  • 15 Molecular phylogenies and the genetic structure of viral populations
  • 16 The genetic population structure of pathogenic bacteria
  • 17 Whole-genome analyses of pathogens
  • 18 What can evolutionary biology contribute to understanding virulence?
  • Part V Non-infectious and degenerative disease
  • 19 Evolution, senescence and health in old age
  • 20 An evolutionary perspective on the genetic architecture of susceptibility to cardiovascular disease
  • 21 The fetal origins of coronary heart disease and stroke: evolutionary implications
  • 22 The evolutionary context of chronic degenerative diseases
  • 23 Testing evolutionary hypotheses about mental disorders
  • 24 The evolution of non-infectious and degenerative disease
  • References
  • Index
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