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DNA Structure and Function , a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. Suitable for graduate courses on DNA structure and nucleic acids, the text is also excellent supplemental reading for courses in general biochemistry, molecular biology, and genetics.

Tabla de contenidos provista por Syndetics

• Introduction to the Structure, Properties, and Reactions of DNA
• DNA Bending
• DNA Supercoiling
• Cruciform Structures in DNA
• Left-Handed Z-DNA
• Triplex DNA
• Miscellaneous Alternative Conformations of DNA
• DNA-Protein Interactions
• The Organization of DNA into Chromosomes
• Author Index
• Subject Index

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CHOICE Review

Sinden does not provide a general description of DNA and its role in biology; there are perhaps enough of those already. Instead, he assumes that the reader knows most of that and spends the first chapter describing the double helix in detail, the chemicals that react with DNA, and the enzymes that modify its structure. From there he launches into the diverse and complex folding patterns imposed upon the double strand itself. Chapters cover supercoiling, cruciform structures, Z-DNA, triplex DNA, parallel-stranded DNA, chromosome folding, and DNA-protein interactions. Each DNA form's potential relationship to natural cellular processes is considered, and each chapter contains a section describing critical experiments and techniques in detail. The style is concise but fluid, and the black-and-white illustrations are simple and appropriately captioned. Author and subject indexes complete this excellent work on an interesting subject. Recommended. Upper-division undergraduate through professional. D. Carmichael; Pittsburg State University