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The human immunodeficiency virus (HIV) commonly enters the central nervous system, disturbs brain function, and ultimately results in serious brain damage. The most serious manifestation of this infection of the brain is HIV-associated dementia, which includes severe memory loss, slowness in thinking, disorientation, and social incapacity. Most persons who are HIV infected do not develop severe dementia; however, perhaps 50% of those with AIDS and a smaller proportion of HIV-infected carriers suffer from more subtle brain disorders that can be revealed by proper neuropsychological testing. This book summarizes the current state of our knowledge about the neurocognitive disorders associated with HIV-1 infection. The book brings together contributions from leading authorities on the prevalence, qualitative features, natural course, and effects of neuropsychological impairments in persons with HIV infection. Neuropsychological data are related to findings from studies of brain imaging, neuropathology, and the effects of antiretroviral treatments.

Tabla de contenidos provista por Syndetics

• I Medical, Immunological, and Neurological Aspects of HIV
• 1 Virology, Immunology, and Clinical Course of HIV Infection
• 2 Immunopathogenesis of HIV Infections: CNS Immune Interactions
• 3 Neurological and Neuropathologic Manifestations of HIV Infection
• 4 Structural Brain Imaging of HIV Infection
• II Neuropsychological Aspects of HIV: Issues, Approaches, and Findings
• 5 The Dementias and AIDS
• 6 Methodological and Conceptual Issues in the Study of Cognitive Change in HIV-Infected Persons
• 7 The Use of a Computerized Battery to Assess Cognition in HIV-Positive Individuals
• 8 Development of a Screening Battery for HIV-Related Cognitive Impairment: The MACS Experience
• 9 The Utility of Clinical Ratings for Detecting Cognitive Change in HIV Infection
• 10 Everyday Functioning and its Relationship to Cognitive Impairment in HIV Disease
• 11 Neuropsychological Assessment of Seropositive Intravenous Drug Users
• 12 HIV, Cognition, and the Basal Ganglia
• 13 Neuroimaging in HIV Infection: Neurospychological and Pathological Correlation
• 14 Neuropsychological Responses to Antiretroviral Therapy in HIV Infection
• 15 The Use of Methylphenidate in HIV Patients: A Clinical Perspective
• 16 Developmental Deficits and Behavioral Change in Pediatric AIDS
• 17 Motor and Cognitive Functioning in Nonhuman Primates Infected with Simian Immunodefiency Virus

Notas de autor provistas por Syndetics

Igor Grant is at Veterans Affairs Medical Center, San Diego. Alex Martin is at National Institute of Mental Health.