Tabla de contenidos provista por Syndetics

• Discovery and Origin of HIV
• Discovery of the AIDS Virus
• The HIV Virion
• Origin of HIV
• Features of HIV Transmission
• HIV in Blood
• HIV in Genital Fluids
• HIV in Saliva and Other Body Fluids
• HIV Transmission by Blood and Blood Products
• Sexual Transmission of HIV
• Maternal-Child Transmission of HIV
• Steps Involved in HIV: Cell Interaction and Virus EntryCD4 Receptor
• Post-Binding Steps in Virus Entry
• Virus: Cell Fusion
• Other Possible Virus: Cell Surface Interactions Involved in Entry
• Down-modulation of the CD4 Protein
• Presence of other Cellular Receptors: Infection of Cells lacking CD4 Expression
• Cell to Cell Transfer of HIV
• Overview of early steps in HIV Infection
• Other potential mechanisms involved in HIV entry into cells
• Recombination
• Acute HIV Infection and Cells Susceptible to HIV Infection
• Acute HIV Infection
• Cells and Tissues infected by HIV
• The Number of CD4 and Lymphocytes infected by HIV
• Interference and Superinfection
• Intracellular Control of HIV Replication
• Early intracellular events in HIV Infection
• Differences in Virus production: Role of intracellular factors
• Effect of other viruses on HIV Replication
• Virus infection of Quiescent Cells
• Latency
• Cytopathic Properties of HIV
• HIV Induction of Cell Fusion
• Viral extrachromosomal DNA accumulation and cell death
• Toxicity of the Virus and Viral Proteins
• Apoptosis
• Role of Superantigens
• Heterogeneity of HIV and its Relation to PathogenesisHIV-2
• Cellular host range differences among HIV-1 strains
• Modulation of CD4 Protein Expression
• Cytopathology
• Latency
• Molecular features
• Serologic properties
• Sensitivity to cell-mediated immune responses
• Relation of HIV Heeterogeneity to Pathogenesis
• Viral Regions Determining Biologic Features of HIV-1Envelope region and cell Tropism
• Regulatory proteins and virus replication
• Envelope region and cytopathicity, CD4 Modulation, and sCD4 Neutralization
• Conclusions
• Effect of HIV on Different tissues and Organ Systems in the Host
• Hematopoietic System: Immune Function
• Central nervous system
• Gastrointestinal system
• Effect of HIV on the function of other organ systems
• Humoral Immune Responses to HIV Infection
• Detection of Anti-HIV Antibodies
• Neutralizing antibodies
• Enhancing antibodies
• Antibody-directed Cellular Cytotoxicity and Antibody-dependent Cytotoxicity
• Complement fixing antiviral antibodies
• Complement
• Autoimmunity
• Cell-Mediated Immune Responses in HIV Infection
• General observations
• Cytotoxic NK Cells
• CD4 and Cell Function
• Cytotoxic CD8 and Cells
• CD8 and Cell suppressing activity
• Cell-mediated antiviral immune responses in uninfected HIV-exposed high-risk individuals
• Antiviral responses at Mucosal surfaces
• HIV Infection and Development of Cancer
• Introduction
• Kaposi's Sarcoma
• B Cell lymphomas
• Anal Carcinoma
• Cervical Carcinoma
• Other Lymphomas
• Summary
• Overall Features of HIV Pathogenesis: Prognosis for Long-term Survival
• Co-factors in HIV Infection and disease progression
• Features of HIV Pathogenesis
• Prognosis
• Difference in clinical outcomes of infected individuals
• Factors involved in long-term survival
• High-risk exposed Seronegative individuals
• Conclusions: Viral and Immunologic features of HIV Pathogenesis
• Antiviral Therapies
• Anti-HIV Therapies
• Effect of Aniretroviral therapy on virus present in other tissues
• Immunologic effects of antiretroviral therapy
• Immune based therapies
• Immune restoration
• Post-infection immunization
• Passive immunotherapy and use of antibody-based approaches
• Vaccine Development
• Introduction
• Inactivated and attenuated viruses
• Vaccines using purified Enveloped gp120 alone or in association with an Expression Vector
• Viral cores as vaccines
• Viral DNA inoculation
• Cytokine enhancement
• Induction of Mucosal immunity
• Human vaccine trials
• Other anti-HIV prevention approaches