Long-range control of gene expression edited by Veronica van Heyningen, Robert E. Hill.

Colaborador(es):

Series Advances in genetics ; v. 61Detalles de publicación: Amsterdam Boston Elsevier Academic Press c2008Descripción: xv, 399 p. ill. 24 cmISBN:

9780123738813
0123738814

Tema(s):

Contenidos:

Chromatin structure and the regulation of gene expression: the lessons of PEV in Drosophila Jack R. Girton and Kristen M. Johansen -- Polycomb group proteins and long-range gene regulation Julio Mateos-Langerak and Giacomo Cavalli -- Evolution of cis-regulatory sequences in Drosophila Pat Simpson and Savita Ayyar -- [Beta] -globin regulation and long-range interactions Robert-Jan Palstra, Wouter de Laat, and Frank Grosveld -- Long-range regulation of [alpha] -globin gene expression Douglas R. Higgs, Douglas Vernimmen, and Bill Wood -- Global control regions and regulatory landscapes in vertebrate development and evolution Francois Spitz and Denis Duboule -- Regulation of imprinting in clusters: noncoding RNAs versus insulators Le-Ben Wan and Marisa S. Bartolomei -- Genomic imprinting and imprinting defects in humans Bernhard Horsthemke and Karin Buiting -- Epigenetic gene regulation in cancer Esteban Ballestar and Manel Esteller -- Genomic identification of regulatory elements by evolutionary sequence comparison and functional analysis Gabriela G. Loots -- Regulatory variation and evolution: implications for disease Emmanouil T. Dermitzakis -- Organization of conserved elements near key developmental regulators in vertebrate genomes Adam Woolfe and Greg Elgar -- Long-range gene control and genetic disease Dirk A. Kleinjan and Laura A. Lettice.

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Descripciones mejoradas de Syndetics:

Long-Range Control of Gene Expression covers the current progress in understanding the mechanisms for genomic control of gene expression, which has grown considerably in the last few years as insight into genome organization and chromatin regulation has advanced.

Includes bibliographical references and index.

Tabla de contenidos provista por Syndetics

Contributors(p. xi)
Preface(p. xiii)
1 Chromatin Structure and the Regulation of Gene Expression: The Lessons of PEV in Drosophila(p. 1)
I Introduction: Position Effect in Drosophila(p. 2)
II Historical Background of the PEV Phenotype(p. 5)
III Types of PEV(p. 8)
IV Genome Organization and PEV(p. 19)
V Concluding Remarks(p. 29)
References(p. 31)
2 Polycomb Group Proteins and Long-Range Gene Regulation(p. 45)
I Introduction(p. 46)
II Genetic and Biochemical Characterization of PcG Proteins(p. 48)
III PcG Mechanisms of Action(p. 49)
IV PcG Proteins and Long-Range Gene Silencing(p. 53)
V PcG and Very Long-Range Gene Silencing: "Teleregulation" of Gene Expression(p. 57)
VI Conclusions and Prospects(p. 61)
References(p. 62)
3 Evolution of Cis-Regulatory Sequences in Drosophila(p. 67)
I Introduction(p. 68)
II Developmental Homeostasis, Sequence Turnover, and Stabilizing Selection(p. 72)
III Enhancer Evolution and Loss or Gain of Traits(p. 84)
IV Cis-Trans Coevolution(p. 91)
V Evolution of New Regulatory Modules(p. 95)
VI Conclusions(p. 98)
References(p. 99)
4 [beta]-Globin Regulation and Long-Range Interactions(p. 107)
I Introduction(p. 108)
II The [beta]-Globin Locus(p. 109)
III Models of Long-Range Control of Gene Expression by Enhancers(p. 115)
IV Long-Range Activation by the [beta]-Globin LCR(p. 117)
V Enhancement of Transcription by the [beta]-Globin LCR: Rate-Limiting Steps(p. 127)
VI The Concept of an Active Chromatin Hub(p. 131)
VII Future Directions(p. 132)
References(p. 133)
5 Long-Range Regulation of [alpha]-Globin Gene Expression(p. 143)
I Introduction(p. 144)
II The Normal Structure and Evolution of the [alpha]-Globin Cluster(p. 146)
III Functional Analysis of the [alpha]-Globin Regulatory Domain(p. 147)
IV Structure of the Upstream Regulatory Elements and the Promoters(p. 152)
V Transcription Factors Involved in Erythropoiesis(p. 153)
VI Cellular Resources for Studying the Key Stages of Hematopoiesis(p. 157)
VII Transcription Factor Binding to the Upstream Regulatory Elements(p. 158)
VIII Transcription Factor Binding to the Promoter(p. 159)
IX The Recruitment of RNA Polymerase and GTFs to the [alpha]-Globin Cluster(p. 160)
X What Role Do the Remote Regulatory Elements Play?(p. 161)
XI How Do the Upstream Elements Interact with the Promoter?(p. 162)
XII Sequential Activation of the [alpha]-Globin Gene Cluster During Differentiation(p. 165)
XIII Conclusions, Speculation, and Future Directions(p. 166)
References(p. 169)
6 Global Control Regions and Regulatory Landscapes in Vertebrate Development and Evolution(p. 175)
I Introduction(p. 176)
II Global Controls(p. 178)
III Co-Expression Chromosomal Territories, Regulatory Landscapes, and Global Control Regions(p. 185)
IV Mechanims of Underlying Global Regulation(p. 188)
V Co-Expression Chromosomal Territories, Regulatory Landscapes: Bystander Effects or Functional Operons?(p. 192)
VI Evolutionary Implications of Global Gene Control(p. 195)
VII Global Regulation, Chromosomal Architecture, and Genetic Disorders(p. 197)
VIII Concluding Remarks(p. 197)
References(p. 198)
7 Regulation of Imprinting in Clusters: Noncoding RNAs Versus Insulators(p. 207)
I Introduction(p. 208)
II Insulator Model of Regulation(p. 209)
III The ncRNA Model of Regulation(p. 212)
IV Dlk1/Gtl2 Imprinted Cluster: A Bit of Everything(p. 215)
V Conclusions(p. 218)
References(p. 219)
8 Genomic Imprinting and Imprinting Defects in Humans(p. 225)
I Introduction(p. 226)
II The Mechanisms of Genomic Imprinting(p. 226)
III Imprinting Defects(p. 230)
IV Conclusions(p. 242)
References(p. 243)
9 Epigenetic Gene Regulation in Cancer(p. 247)
I Introduction(p. 248)
II Cancer Cells Show A Disruption of DNA Methylation Patterns(p. 250)
III Disruption of the Histone Modification Profile in Cancer(p. 253)
IV Cascades of Epigenetic Deregulation in Cancer(p. 256)
V What Are the Mechanisms That Lead to Aberrant Methylation Patterns in Cancer?(p. 258)
VI Epigenetic Therapy for Cancer Treatment(p. 261)
References(p. 262)
10 Genomic Identification of Regulatory Elements by Evolutionary Sequence Comparison and Functional Analysis(p. 269)
I Introduction(p. 270)
II Genomic Architecture of the Human Genome(p. 271)
III Computational Methods of Predicting Regulatory Elements(p. 276)
IV In Vivo Validation and Characterization of Transcriptional Regulatory Elements(p. 282)
V Conclusions(p. 286)
References(p. 287)
11 Regulatory Variation and Evolution: Implications for Disease(p. 295)
I Introduction(p. 296)
II Evolution and Variation of Noncoding DNA(p. 297)
III Natural Selection in Noncoding DNA(p. 300)
IV Gene Expression Studies(p. 301)
V Disease Implications(p. 302)
VI Conclusions(p. 303)
References(p. 304)
12 Organization of Conserved Elements Near Key Developmental Regulators in Vertebrate Genomes(p. 307)
I Introduction(p. 308)
II Gene-Regulatory Networks in Development(p. 309)
III Identification of Evolutionarily Constrained Sequences Using Phylogenetic Footprinting(p. 310)
IV Searches for Regulatory Elements Using Evolutionary Conservation(p. 310)
V Takifugu Rubripes: A Compact Model Genome(p. 312)
VI Identification of Enhancer Elements Through Fish-Mammal Comparisons(p. 313)
VII Fish-Mammal Conserved Noncoding Elements Are Associated with Vertebrate Development(p. 315)
VIII High-Resolution Analysis of the Organization of CNEs Around Key Developmental Regulators(p. 317)
IX General Genomic Environment Around CNEs(p. 317)
X CNEs Present in Transcripts(p. 319)
XI CNEs Located Within UTRs(p. 321)
XII CNEs Are Located Large Distances Away from Their Putative Target Gene(p. 323)
XIII Discussion(p. 328)
References(p. 333)
13 Long-Range Gene Control and Genetic Disease(p. 339)
I From Genetic Disease to Long-Range Gene Regulation(p. 340)
II Position Effect Revisited(p. 342)
III Loss of a Positive Regulator(p. 345)
IV TWIST, POU3F4, PITX2, SOX3, GLI3, and FOXP2(p. 346)
V The "Bystander" Effect(p. 353)
VI MAF, SDC2, TGFB2, REEP3, and PLP1(p. 355)
VII Two Position Effects-Different Outcomes(p. 357)
VIII Phenotypes Resulting from Position Effects on More than One Gene(p. 362)
IX Global Control Regions; HOXD, Gremlin, and Limb Malformations(p. 363)
X FOX Genes and Position Effects(p. 365)
XI SOX9 and Campomelic Displasia(p. 366)
XII Facioscapulohumeral Dystrophy(p. 368)
XIII Aberrant Creation of an Illegitimate siRNA Target Site(p. 370)
XIV Genetic Disease Due to Aberrant Gene Transcription Can Be Caused by Many Different Mechanisms(p. 371)
XV Concluding Remarks(p. 378)
References(p. 379)
Index(p. 389)

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