Huether, Sue E. creator author McCance, Kathryn L. author Brashers, Valentina L. author miu 2026 Eight edition eng xviii, 1113 pages : illustrations ; 28 cm. Gain an in-depth understanding of the concepts and processes of disease! Understanding Pathophysiology, 8th Edition provides a concise, comprehensive introduction to the way diseases work and how changes occur in the body as a result. With a clinically focused approach, the book begins by explaining cell structure and function. It then examines alterations by body systems and provides a practical guide to clinical manifestations, summaries of treatment, and health promotion strategies. This edition adds new algorithms, case studies for the Next-Generation NCLEX® Exam, and updated content on COVID-19, obesity, and cancer epidemiology. Written by a team of nursing educators led by Sue Huether, this text helps you develop clinical judgment and apply concepts to practice. Introduction to Pathophysiology -- 1. Cellular Biology -- 2. Genes and Genetic Diseases -- 3. Epigenetics and Disease -- 4. Altered Cellular and Tissue Biology -- 5. Fluids and Electrolytes, Acids and Bases -- 6. Innate Immunity: Inflammation and Wound Healing -- 7. Adaptive Immunity -- 8. Alterations of Immunity -- 9. Infection -- 10. Stress and Disease -- 11. Cancer Biology -- 12. Cancer Epidemiology -- 13. Cancer in Children and Adolescents -- 14. Structure and Function of the Neurologic System -- 15. Pain, Temperature, Sleep, and Sensory Function -- 16. Alterations of Cognitive Systems, Cerebral Hemodynamics, and Motor Function -- 17. Alterations of the Brain, Spinal Cord, and Peripheral Nerves -- 18. Alterations of Neurologic Function in Children -- 19. Mechanisms of Hormonal Regulation -- 20. Alterations of Hormonal Regulation -- 21. Obesity, Starvation, and Anorexia of Aging -- 22. Structure and Function of the Hematologic System -- 23. Alterations of Hematologic Function -- 24. Alterations of Hematologic Function in Children -- 25. Structure and Function of the Cardiovascular and Lymphatic Systems -- 26. Alterations of Cardiovascular Function -- 27. Alterations of Cardiovascular Function in Children -- 28. Structure and Function of the Pulmonary System -- 29. Alterations of Pulmonary Function -- 30. Alterations of Pulmonary Function in Children -- 31. Structure and Function of the Renal and Urologic Systems -- 32. Alterations of Renal and Urinary Tract Function -- 33. Alterations of Renal and Urinary Tract Function in Children -- 34. Structure and Function of the Reproductive Systems -- 35. Alterations of the Female Reproductive System -- 36. Alterations of the Male Reproductive System -- 37. Structure and Function of the Digestive System -- 38. Alterations of Digestive Function -- 39. Alterations of Digestive Function in Children -- 40. Structure and Function of the Musculoskeletal System -- 41. Alterations of Musculoskeletal Function -- 42. Alterations of Musculoskeletal Function in Children -- 43. Structure, Function, and Disorders of the Integument -- 44. Alterations of the Integument in Children -- Prefixes and Suffixes Used in Medical Terminology -- Word Roots Commonly Used in Medical Terminology. Sue E. Huether, Kathryn L. McCance, Valentina L. Brashers. Includes bibliographical references and index. Physiology , Pathological Nurses Disease RB113 .H77 2026 9780323937283 120830 20250923143123.0