TY - BOOK AU - Colacino,Evelina AU - García,Felipe TI - Mechanochemistry and emerging technologies for sustainable chemical manufacturing SN - 9780367775018 AV - QD850 .M433 2023 U1 - 541/.39 23/eng20230511 PY - 2024/// CY - Boca Raton, Florida PB - CRC Press KW - Mechanical chemistry KW - Chemical processes KW - Technological innovations N1 - Includes bibliographical references and index; Introduction : overview of book : objective of book : scaling up sustainable synthesis by mechanochemistry / Deborah Crawford, Felipe Garcia and Evelina Colacino -- Mechanochemistry : a brief historical introduction / Seplak Vladimir and Senna Mamoru -- In situ monitoring of mechanochemical reaction by Raman/PXRD / Ivan Halasz -- Kinetics and thermodynamics of mechanochemical reactions : a computational approach / Feliu Maseras -- The thermodymanics and kinetics of mechanochemical reactions : an experimental approach / Adam Michalchuk -- Life cycle assessment / Sabrina Spatari -- Intellectual properties in mechanochemistry / Tanja Benele -- Mechanochemistry at scale : the ultimate process intensification and beyond including continuous mechanochemical synthesis by twin screw extrusion Identification of important parameters moving forward / Valerio Isoni -- Batch mechanochemical synthesis : scale-up / Michael Fellderhoff -- Acoustic synthesis (solvent-free) and resonant acoustic mixing (RAM) / Maria Rivas-Velazco -- Case study : sustainable large scale manufacturing of fine chemicals, APIs and biologically active compounds / Bela Torok -- Case study : Siebtechnik Company (DE) and eccentric mills / Peter Balaz -- Scalable solutions for continuous manufacturing by mechanochemical-assisted synthesis / Duncan Browne -- Large scale continuous flow chemistry / Darren Riley -- Sustainable chemical manufacture in water : An industrial point of view / Fabrice Gallou N2 - "This unique volume describes advances in the field of mechanochemistry, in particular the scaling up of mechanochemical processes. Scalable techniques employed to carry out solvent-free synthesis are evaluated. Comparability to continuous flow chemistry, the current industrial benchmark for continuous efficient chemical synthesis, is presented. The book concludes that mechanochemical synthesis can be scaled up into a continuous, sustainable process. It demonstrates that large scale mechanochemistry can meet industrial demands especially in the pharmaceutical industry. The case studies conducted on MOF Technologies and Deasyl demonstrate how mechanochemistry is employed on a pilot plant scale"-- ER -