Hematology and Coagulation : A Comprehensive Review for Board Preparation, Certification and Clinical Practice /
Amer Wahed, Andres Quesada, and Amitava Dasgupta.
- Second edition
- 1 online resource (326 pages)
ALA COVID Relief Fund
Front Cover -- Hematology and Coagulation -- Hematology and Coagulation -- Copyright -- Dedication -- Contents -- Preface -- 1 - Complete blood count and peripheral smear examination -- Introduction -- Analysis of various parameters by hematology analyzers -- Histograms -- Red blood cell histogram -- Platelet histogram -- White blood cell histogram -- Red blood cell count and hemoglobin measurement -- Hematocrit, RDW, MCV, MCH, and MCHC -- Reticulocyte count -- White blood cell count and differential -- Platelet count, mean platelet volume, platelet differential width -- Review of peripheral smear -- Red cell variations and inclusions -- White blood cell morphology -- Platelets -- Special situations with complete blood count and peripheral smear examination -- Splenic atrophy or postsplenectomy -- Microangiopathic hemolysis -- Leukoerythroblastic blood picture -- Parasites, microorganisms and nonhematopoietic cells in the peripheral blood -- Buffy coat preparation -- Key points -- References -- 2 - Bone marrow examination and interpretation -- Introduction -- Fundamentals of bone marrow examination -- Dry tap -- Granulopoiesis -- Erythropoiesis -- Monopoiesis, megakaryopoiesis, thrombopoiesis, and other cells in bone marrow -- Various bone marrow examination findings and bone marrow failure -- Disorders of erythropoiesis, granulopoiesis, and thrombopoiesis -- Infections -- Granulomatous changes -- Storage disorders -- Metabolic bone diseases -- Metastatic tumors -- Hemophagocytic syndrome -- Bone marrow necrosis/infarction -- Serous atrophy -- Bone marrow fibrosis -- Reactive lymphoid aggregate -- Bone marrow infiltration in lymphoproliferative disorders -- Amyloidosis -- Key points -- References -- 3 - Red blood cell disorders -- Introduction -- Anemia: morphological and etiological classification -- Common causes of anemia. Dimorphic red cells -- Anemia due to blood loss -- Iron deficiency anemia -- Lead poisoning -- Anemia of chronic disease -- Sideroblastic anemia -- Megaloblastic anemia -- Bone marrow failure -- Congenital dyserythropoietic anemia -- Hemolytic anemia -- Hemolytic anemia due to corpuscular defects -- Hemolytic anemia due to membrane defects -- Hereditary spherocytosis (aka Minkowski-Chauffard disease) -- Hereditary elliptocytosis -- Hereditary pyropoikilocytosis -- Hereditary stomatocytosis -- Rh null disease -- Hemolytic anemia due to enzyme defects -- Pyruvate kinase deficiency -- Glucose-6-phosphate dehydrogenase deficiency -- Paroxysmal nocturnal hemoglobinuria -- Hemolytic anemias due to extracorpuscular defects -- Red cell poikilocytosis -- Red cell inclusions -- Malaria parasites -- Key points -- References -- 4 - Hemoglobinopathies and thalassemias -- Introduction -- Hemoglobin structure and synthesis -- Introduction to hemoglobinopathies and thalassemias -- α-thalassemia -- Diagnosis of α-thalassemias -- β-thalassemia -- Diagnosis of β-thalassemia -- β-Thalassemia trait -- β-Thalassemia major -- δ-thalassemia -- δβ-Thalassemia -- Sickle cell disease -- Diagnostic approach to an individual who demonstrates HbS on electrophoresis -- Diagnosis of sickle cell trait -- Diagnosis of sickle cell trait with concomitant α-thalassemia trait -- Diagnosis of sickle cell disease -- Diagnosis of sickle cell disease patient who has been transfused or has undergone red blood cell exchange -- Diagnosis of sickle cell/β-thalassemia (this in turn can be S/β 0- or S/β+- or S/β++ thalassemia) -- Diagnosis of sickle cell disease patient on hydroxyurea -- Diagnosis of Hb SC disease -- Diagnosis of HbS/hereditary persistence of fetal hemoglobin -- Diagnosis of normal individual who has been transfused red blood cells from a sickle cell trait donor. Hereditary persistence of fetal hemoglobin -- Other hemoglobin variants -- Individuals with high hemoglobin F -- Fast, unstable, and other rare hemoglobins -- Laboratory investigation of hemoglobinopathies -- Gel electrophoresis -- High-performance liquid chromatography -- Capillary electrophoresis -- Reporting normal hemoglobin electrophoresis pattern -- Apparent hemoglobinopathy after blood transfusion -- Universal newborn screen -- Key points -- References -- 5 - Benign white blood cell and platelet disorders -- Introduction -- Hereditary variation in white blood cell morphology -- Changes in white cell counts -- Neutrophilia -- Eosinophilia and monocytosis -- Basophilia -- Neutropenia -- Lymphocytosis and infectious mononucleosis -- Lymphocytopenia -- Platelet disorders -- Thrombocytopenias -- Thrombocytosis -- Thrombocytopathia -- Key points -- References -- 6 - Myeloid neoplasms -- Introduction -- Classification of myeloid neoplasms -- Myeloproliferative neoplasm -- Chronic myeloid leukemia, BCR-ABL1 positive -- Chronic neutrophilic leukemia -- Polycythemia vera, primary myelofibrosis, and essential thrombocythemia -- Chronic eosinophilic leukemia -- Myeloproliferative neoplasm, unclassifiable -- Mastocytosis -- Myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement -- Myelodysplastic/myeloproliferative neoplasms -- Myelodysplastic syndromes -- Features of dysplasia in red cells, erythroid precursors, granulocytes and megakaryocytes -- Arriving at a diagnosis of MDS and subclassifying MDS -- Abnormal localization of immature precursors -- Cytogenetic abnormalities associated with myelodysplastic syndrome -- Unusual situations in myelodysplastic syndrome -- Myeloid neoplasms with germline predisposition -- Acute leukemia -- Blasts -- Cytochemistry -- Classification of acute myeloid leukemia and diagnosis. Acute myeloid leukemia with recurrent genetic abnormalities -- Acute myeloid leukemia, not otherwise specified -- Myeloid sarcoma -- Myeloid proliferations associated with Down syndrome -- Acute myeloid leukemia and flow cytometry -- Molecular and acute myeloid leukemia -- Cytogenetics and acute myeloid leukemia -- Key points -- References -- 7 - Monoclonal gammopathies and their detection -- Introduction -- Diagnostic approach to monoclonal gammopathy using electrophoresis -- Serum protein electrophoresis -- Urine electrophoresis -- Immunofixation studies -- Capillary zone electrophoresis -- Free light chain assay -- Heavy/light chain assay -- Paraprotein interferences in clinical laboratory tests -- Plasma cell disorders -- Monoclonal gammopathy of undetermined significance -- Idiopathic Bence Jones proteinuria -- Monoclonal gammopathy of renal significance -- POEMS -- Plasmacytoma -- Monoclonal immunoglobin deposition disease (MIDD) -- Plasma cell myeloma -- Morphology of plasma cells in myeloma -- Immunophenotype of neoplastic plasma cells -- Cytogenetics in myeloma diagnosis -- Key points -- References -- 8 - Application of flow cytometry in diagnosis of hematological disorders -- Introduction -- Flow cytometry and mature B-cell lymphoid neoplasms -- B-cell markers -- Chronic lymphocytic leukemia/small lymphocytic lymphomas -- B-cell prolymphocytic leukemia -- Mantle cell lymphoma -- Follicular lymphoma -- Hairy cell leukemia -- Burkitt lymphoma -- Diffuse large B-cell lymphoma -- Flow cytometry and mature T and natural killer-cell lymphoid neoplasm -- Detection of clonal or restricted population of T and natural killer cells -- Sézary syndrome and mycosis fungoides -- T-cell prolymphocytic leukemia -- T-cell large granular lymphocytic leukemia -- Chronic lymphoproliferative disorder of natural killer cells -- Plasma cell dyscrasias. Flow cytometry and acute leukemia -- Flow cytometry and subtypes of acute myeloid leukemia -- Flow cytometry of B-lymphoblastic leukemia/lymphoma -- Flow cytometry of T-lymphoblastic leukemia/lymphoma -- Flow cytometry of mixed phenotype acute leukemia -- Flow cytometry of blastic plasmacytoid dendritic cell neoplasm -- Flow cytometry and myelodysplastic syndrome -- Flow cytometry and hematogones -- Key points -- References -- 9 - Cytogenetic and genetic abnormalities in hematologic neoplasms -- Introduction -- Cytogenetic abnormalities in chronic myeloid leukemia -- Cytogenetic abnormalities in myelodysplastic syndrome -- Cytogenetic abnormalities in patients with myeloid malignancies -- Cytogenetic abnormalities in myeloproliferative neoplasms -- Cytogenetic abnormalities in acute lymphoblastic leukemia -- Cytogenetic abnormalities in multiple myeloma -- Cytogenetic and genetic abnormalities in B- and T-cell lymphomas -- Key points -- References -- 10 - Benign lymph node -- Introduction -- Reactive lymphoid states -- Viral lymphadenopathy -- Bacterial infections and lymphadenopathy -- Cat-scratch lymphadenopathy -- Toxoplasma gondii and lymphadenopathy -- Granulomatous lymphadenopathy -- Necrotizing lymphadenopathy -- Progressive transformation of germinal centers -- Regressive changes in germinal center -- Specific clinical entities with lymphadenopathy -- Kikuchi-Fujimoto disease -- Kimura disease -- Kawasaki disease -- Dermatopathic lymphadenitis -- Lymphadenopathy in autoimmune diseases -- Rosai-Dorfman disease -- Langerhans cell histiocytosis -- Castleman disease -- IgG4-related sclerosing disease-associated lymphadenopathy -- Key points -- References -- 11 - Precursor lymphoid neoplasms, blastic plasmacytoid dendritic cell neoplasm, and acute leukemias of ambiguous l ... -- Introduction -- B-lymphoblastic leukemia/lymphoma, NOS. Morphology and immunophenotype.
Hematology and Coagulation: A Comprehensive Review for Board Preparation, Certification and Clinical Practice, Second Edition, takes a practical and easy-to-read approach to understanding hematology and coagulation at an appropriate level for both board preparation and refresher courses. The book bridges the gap between large textbooks and medical technology books written for laboratory technicians, providing the sufficient background in genetics, toxicology and immunology that residents and medical students need to know in order to become successful physicians. Readers will use this quick reference to understand how tests are performed and how to interpret results. This clear and easy-to-read presentation of core topics and detailed case studies illustrates the application of hematopathology on patient care. Provides a newly updated source that's in accordance with World Health Organization guidelines on the diagnosis of hematological malignancies Succinctly covers all important clinical information found in larger textbooks in an easy-to-understand manner Highlights essential concepts in hematopathology in such a way that pathology fellows and clinicians can understand methods without being specialists in the field.