TY - BOOK AU - Rao,D.C. TI - Genetic dissection of complex traits T2 - Advances in genetics SN - 9780123738837 (hbk.) U1 - 616.042 22 PY - 2008/// CY - London PB - Academic KW - Medical genetics KW - Local KW - Genetic epidemiology KW - Syndromes KW - Genetic aspects N1 - Previous ed.: 2001; 1; An overview of the genetic dissection of complex traits; D. C. Rao --; 2; Familial resemblance and heritability; Treva K. Rice --; 3; Linkage and association: basic concepts; Ingrid B. Borecki and Michael A. Province --; 4. Definition of phenotype; Mary K. Wojczynski and Hemant K. Tiwari --; 5; Genotyping platforms for mass-throughput genotyping with SNPs, including human genome-wide scans / Karen Maresso and Ulrich Broeckel --; 6; Genotyping errors and their impact on genetic analysis; Michael B. Miller, Karen Schwander, and D. C. Rhao --; 7; Model-based methods for linkage analysis; John P. Rice, Nancy L. Saccone, and Jonathan Corbett --; 8; Contemporary model-free methods for linkage analysis; Laura Almasy and John Blangero --; 9; DNA sequence-based phenotypic association analysis; Nicholas J. Schork, Jennifer Wessel, and Nathalie Malo --; 10; Family-based methods for linkage and association analysis; Nan M. Laird and Christoph Lange --; 11; Searching for additional disease loci in a genomic region; Glenys Thomson, Lisa F. Barcellos, and Ana M. Valdes --; 12; Methods for handling multiple testing; Treva K. Rice, Nicholas J. Schork, and D. C. Rao --; 13; Meta-analysis methods; Thomas A. Trikalinos, Georgia Salanti, Eias Zintzaras, and John P. A. Ioannidis --; 14; Haplotype-association analysis; Nianjun Liu, Kui Zhang, and Hongyu Zhao --; 15; Characterization LD structures and the utility of HapMap in genetic association studies; C. Charles Gu, Kai Yu, and D. C. Rao --; 16; Associations among multiple markers and complex disease: models, algorithms, and applications; Themistocles L. Assimes, Adam B. Olshen, Balasubramanian Narasimhan, and Richard A. Olshen --; 17; Study designs for genome-wide association studies; Peter Kraft and David G. Cox --; 18; Ethical, legal, and social implications of biobanks for genetics research; Susanne B. Haga and Laura M. Beskow --; 19; Admixture mapping and the role of population structure for localizing disease genes; Xiaofeng Zhu, Hua Tang, and Neil Risch --; 20; Integrating global gene expression analysis and genetics; Clarles R. Farber and Aldons J. Lusis --; 21; A systems biology approach to drug discovery; Jun Zhu, Bin Zhang, and Eric E. Schadt --; 22; The promise of composite likelihood methods for addressing computationally intensive challenges; Na Li --; 23; Comparative genomics for detecting human disease genes; Carol Moreno, Jozef Lazar, Howard J. Jacob, and Anne E. Kwitek --; 24; From genetics to mechanism of disease liability; Andreas Rohrwasser, Paul Lott, Robert B. Weiss, and Jean-Marc Lalouel --; 25; Into the Post-HapMap era; Newton E. Morton ER -