TY  - BOOK
AU  - Boelsterli,Urs A.
TI  - Mechanistic toxicology: the molecular basis of how chemicals disrupt biological targets
SN  - 0849372720
AV  - RA1220.3 .B64 2007
U1  - 615.9 22
PY  - 2007///
CY  - Boca Raton
PB  - CRC Press
KW  - Molecular toxicology
KW  - Local
N1  - Includes bibliographical references and index; Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology
UR  - http://www.loc.gov/catdir/enhancements/fy0703/2006035219-d.html
ER  -