the molecular basis of how chemicals disrupt biological targets Boelsterli, Urs A. creator text bibliography flu Boca Raton CRC Press c2007 2007 2nd ed. monographic eng

print

399 p. ill. 25 cm. Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology. Urs A. Boelsterli. Includes bibliographical references and index. Molecular toxicology RA1220.3 .B64 2007 615.9 B6718m2 2007 F-245 QV 602 B671n 2007 0849372720 2006035219 http://www.loc.gov/catdir/enhancements/fy0703/2006035219-d.html http://www.loc.gov/catdir/enhancements/fy0703/2006035219-d.html 061020 20160527200609.0 283244