01873nam a2200301Ia 4500 283244 OCoLC 20160527200609.0 061020s2007 flua b 001 0 eng 2006035219 0849372720 (OCoLC)74459862 pcc PUXA RA1220.3 .B64 2007 2007 F-245 QV 602 B671n 2007 615.9 B6718m2 22 Boelsterli, Urs A. Local 63467 Mechanistic toxicology the molecular basis of how chemicals disrupt biological targets Urs A. Boelsterli. 2nd ed. Boca Raton CRC Press c2007. 399 p. ill. 25 cm. Includes bibliographical references and index. Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology. Molecular toxicology. Local 137566 Publisher description http://www.loc.gov/catdir/enhancements/fy0703/2006035219-d.html 204287 204287 0 0 ddc 0 615_900000000000000_B6718M2 0 evl 306862 10 10 1 2016-05-27 Amazon 65.04 412671 0 615.9 B6718m2 80000002330085 2016-05-27 00:00:00 r:283244 6