01799nam a2200277Ia 4500001000700000003000600007005001700013008004100030010001700071020001500088035002000103042000800123050002400131060001500155060002300170082002300193100003000216245011200246250001200358260003400370300002500404504005100429505091700480650003301397856009101430283244OCoLC20160527200609.0061020s2007    flua     b    001 0 eng    a  2006035219  a0849372720  a(OCoLC)74459862  apcc00aRA1220.3b.B64 200700a2007 F-24510aQV 602bB671n 200700a615.9bB6718m22221 aBoelsterli, Urs A.2Local10aMechanistic toxicologybthe molecular basis of how chemicals disrupt biological targetscUrs A. Boelsterli.  a2nd ed.  aBoca RatonbCRC Presscc2007.  a399 p.bill.c25 cm.  aIncludes bibliographical references and index.0 aIntroduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology. 0aMolecular toxicology.2Local423Publisher descriptionuhttp://www.loc.gov/catdir/enhancements/fy0703/2006035219-d.html