Boelsterli, Urs A. <br/><br/>
Mechanistic toxicology  the molecular basis of how chemicals disrupt biological targets 
Urs A. Boelsterli. 
 - 2nd ed. 
 - Boca Raton  CRC Press  c2007. 
 - 399 p.  ill.  25 cm. 
<br/><br/>Includes bibliographical references and index. 
<br/><br/>Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology. 
<br/><br/><label>ISBN: </label>0849372720 
<br/><br/><label>LCCN: </label>2006035219 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Molecular toxicology.
<br/><br/><label>LC Class. No.: </label>RA1220.3  / .B64 2007 
<br/><br/><label>Dewey Class. No.: </label>615.9  / B6718m2 
<br/><br/><label>National Library of Medicine Call No.: </label>2007 F-245 QV 602  / B671n 2007