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Practical, approachable, and perfect for today's busy medical students and practitioners, BRS Biochemistry, Molecular Biology, and Genetics , 8th Edition , provides a comprehensive yet concise review to help ensure excellence on class exams and the USMLE Step 1. The renowned Board Review Series outline format offers efficient content review enhanced by key learning aids, clinical correlations, and USMLE-style questions to reinforce understanding and test preparation. Aligned with recent changes in medical education and board exams, this updated edition emphasizes clinically relevant information to boost confidence and support a smooth transition to medical practice. UPDATED! Content reflects the latest clinical approaches, including enhanced coverage of porphyria. UPDATED! More than 750 USMLE-style review questions in the text and available online strengthen retention and test-taking confidence. UPDATED! Clinical Pearls demonstrate the practical application of chapter concepts. Popular Board Review Series outline format saves time and streamlines review. 150-question Comprehensive Exam provides critical board review practice.

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• Preface and Acknowledgements(v)
• How to Use This Book(vii)
• 1 Fuel Metabolism And Nutrition: Basic Principles(1)
• Overview(1)
• I Metabolic Fuels and Dietary Components(1)
• II The Fed or Absorptive State(5)
• III Fasting(7)
• IV Prolonged Fasting (Starvation)(9)
• Review Test(12)
• 2 Basic Aspects of Biochemistry: Organic Chemistry, Acid-Base Chemistry, Amino Aids, Protein Structure and Function, and Enzyme Kinetics(20)
• Introduction(20)
• Overview(20)
• I A Brief Review of Organic Chemistry(20)
• II Acids, Bases, and Buffers(22)
• III Amino Acids and Peptide Bonds(23)
• IV Protein Structure(27)
• V Enzymes(35)
• Review Test(40)
• 3 Genome Maintenance (Replication), Gene Expression (Transcription), Synthesis of Proteins (Translations), and Regulation of Gene Expression(50)
• Overview(50)
• I Nucleic Acid Structure(50)
• II Synthesis of DNA (Replication)(56)
• III Synthesis of RNA (Transcription)(64)
• IV Protein Synthesis (Translation of Messenger RNA)(67)
• V Regulation of Protein Homeostasis(75)
• VI Recombinant DNA and Medicine(86)
• Review Test(95)
• 4 Cell Biology, Signal Transduction, And The Molecular Biology Of Cancer(105)
• Overview(105)
• I Compartmentation in Cells: Cell Biology and Biochemistry(106)
• II Cell Signaling by Chemical Messengers(112)
• III The Molecular Biology of Cancer(121)
• IV Cancer and Apoptosis(127)
• V Cancer Requires Multiple Mutations(128)
• VI Viruses and Human Cancer(129)
• Review Test(130)
• 5 Generation of ATP From Metabolic Fuels and Oxygen Toxicity(140)
• Overview(140)
• I Bioenergetics(140)
• II Properties of Adenosine Triphosphate(142)
• III Electron Carriers and Vitamins(144)
• IV Tricarboxylic Acid Cycle(150)
• V Electron Transport Chain and Oxidative Phosphorylation(155)
• VI Oxygen Toxicity and Free-Radical Injury(159)
• Review Test(165)
• 6 Carbohydrat Metabolism(175)
• Overview(175)
• I Carbohydrate Structure(175)
• II Proteoglycans, Glycoproteins, and Glycolipids(179)
• III Digestion of Carbohydrates(182)
• IV Glycogen Structure and Metabolism(184)
• V Glycolysis(191)
• VI Gluconeogenesis(199)
• VII Fructose and Galactose Metabolism(204)
• VIII Pentose Phosphate Pathway(207)
• IX Maintenance of Blood Glucose Levels(209)
• Review Test(219)
• 7 Lipid And Ethanol Metabolism
• Overview(227)
• I Lipid Structure(229)
• II Membranes(230)
• III Digestion of Dietary Triacylglycerol(231)
• IV Fatty Acid and Triacylglycerol Synthesis(233)
• V Formation of Triacylglycerol Stores in Adipose Tissue(239)
• VI Blood Lipoproteins(240)
• VII Cholesterol and Bile Salt Metabolism(245)
• VIII General Mechanisms of Hormone Action(250)
• IX Fate of Adipose Triacylglycerols(250)
• X Fatty Acid Oxidation(251)
• XI Ketone Body Synthesis and Utilization(256)
• XII Phospholipid and Sphingolipid Metabolism(258)
• XIII Metabolism of the Eicosanoids(261)
• XIV Ethanol Metabolism 263 Review Test(266)
• 8 Tissue Metabolism: Nitrogen-Containing Nutrient Absorption And Digestion, Pathologies Of Nitrogen Metabolism(275)
• I Nitrogen Metabolism Overview(275)
• II Protein Digestion and Amino Acid Absorption(276)
• III Addition and Removal of Amino Acid Nitrogen(278)
• IV Urea Cycle(279)
• V Synthesis and Degradation of Amino Acids(282)
• VI Interrelationships of Various Tissues in Amino Acid Metabolism(290)
• VII Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine(294)
• VIII Special Products Derived From Amino Acids(297)
• IX Biochemical Functions of Tissues(308)
• Review Test(317)
• 9 Human Genetics-An Introduction(327)
• Overview(327)
• I Mendelian Inheritance Patterns(328)
• II Genes(329)
• III Mutations(329)
• IV Inheritance Patterns(330)
• V A Summary of Inheritance Patterns(335)
• VI Cytogenetics(336)
• VII Population Genetics(342)
• VIII Multifactorial Diseases (Complex Traits)(342)
• IX Triplet Repeat Expansions(343)
• X Epigenetics(344)
• XI Imprinting(344)
• XII The Genetics of Tumor Suppressors(346)
• XIII Metabolic Genetic Disorders Involving Carbohydrate and Lipid Pathways(347)
• Review Test(349)
• Comprehensive Examination(357)
• Index(401)