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Extensively revised and updated, this authoritative biochemistry text is known worldwide for its comprehensive and up-to-date coverage. Extensively illustrated and user-friendly, the text offers examples pf how knowledge of biochemistry is essential for understanding the molecular basis of health and disease. The 26th edition also features expanded content on results of the Human Genome Project. Perfect as both text and USMLE review.

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• Authors(p. vii)
• Preface(p. ix)
• 1. Biochemistry & Medicine(p. 1)
• 2. Water & pH(p. 5)
• Section I. Structures & Functions of Proteins & Enzymes(p. 14)
• 3. Amino Acids & Peptides(p. 14)
• 4. Proteins: Determination of Primary Structure(p. 21)
• 5. Proteins: Higher Orders of Structure(p. 30)
• 6. Proteins: Myoglobin & Hemoglobin(p. 40)
• 7. Enzymes: Mechanism of Action(p. 49)
• 8. Enzymes: Kinetics(p. 60)
• 9. Enzymes: Regulation of Activities(p. 72)
• Section II. Bioenergetics & the Metabolism of Carbohydrates & Lipids(p. 80)
• 10. Bioenergetics: The Role of ATP(p. 80)
• 11. Biologic Oxidation(p. 86)
• 12. The Respiratory Chain & Oxidative Phosphorylation(p. 92)
• 13. Carbohydrates of Physiologic Significance(p. 102)
• 14. Lipids of Physiologic Significance(p. 111)
• 15. Overview of Metabolism(p. 122)
• 16. The Citric Acid Cycle: The Catabolism of Acetyl-CoA(p. 130)
• 17. Glycolysis & the Oxidation of Pyruvate(p. 136)
• 18. Metabolism of Glycogen(p. 145)
• 19. Gluconeogenesis & Control of the Blood Glucose(p. 153)
• 20. The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism(p. 163)
• 21. Biosynthesis of Fatty Acids(p. 173)
• 22. Oxidation of Fatty Acids: Ketogenesis(p. 180)
• 23. Metabolism of Unsaturated Fatty Acids & Eicosanoids(p. 190)
• 24. Metabolism of Acylglycerols & Sphingolipids(p. 197)
• 25. Lipid Transport & Storage(p. 205)
• 26. Cholesterol Synthesis, Transport, & Excretion(p. 219)
• 27. Integration of Metabolism--the Provision of Metabolic Fuels(p. 231)
• Section III. Metabolism of Proteins & Amino Acids(p. 237)
• 28. Biosynthesis of the Nutritionally Nonessential Amino Acids(p. 237)
• 29. Catabolism of Proteins & of Amino Acid Nitrogen(p. 242)
• 30. Catabolism of the Carbon Skeletons of Amino Acids(p. 249)
• 31. Conversion of Amino Acids to Specialized Products(p. 264)
• 32. Porphyrins & Bile Pigments(p. 270)
• Section IV. Structure, Function, & Replication of Informational Macromolecules(p. 286)
• 33. Nucleotides(p. 286)
• 34. Metabolism of Purine & Pyrimidine Nucleotides(p. 293)
• 35. Nucleic Acid Structure & Function(p. 303)
• 36. DNA Organization, Replication, & Repair(p. 314)
• 37. RNA Synthesis, Processing, & Modification(p. 341)
• 38. Protein Synthesis & the Genetic Code(p. 358)
• 39. Regulation of Gene Expression(p. 374)
• 40. Molecular Genetics, Recombinant DNA, & Genomic Technology(p. 396)
• Section V. Biochemistry of Extracellular & Intracellular Communication(p. 415)
• 41. Membranes: Structure & Function(p. 415)
• 42. The Diversity of the Endocrine System(p. 434)
• 43. Hormone Action & Signal Transduction(p. 456)
• Section VI. Special Topics(p. 474)
• 44. Nutrition, Digestion, & Absorption(p. 474)
• 45. Vitamins & Minerals(p. 481)
• 46. Intracellular Traffic & Sorting of Proteins(p. 498)
• 47. Glycoproteins(p. 514)
• 48. The Extracellular Matrix(p. 535)
• 49. Muscle & the Cytoskeleton(p. 556)
• 50. Plasma Proteins & Immunoglobulins(p. 580)
• 51. Hemostasis & Thrombosis(p. 598)
• 52. Red & White Blood Cells(p. 609)
• 53. Metabolism of Xenobiotics(p. 626)
• 54. The Human Genome Project(p. 633)
• Appendix(p. 639)
• Index(p. 643)