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Well-known for its authoritative and comprehensive coverage, complete treatment of pediatric pathophysiology, and the most extensive illustration program in its field, this textbook features expert content on everything from the general principles of pathophysiology to detailed discussions of genetics and specific diseases. Chapters on alteration present the pathophysiology, clinical manifestations, and evaluation and treatment of each disease to help you learn to identify normal anatomy and physiology, as well as alterations of function in adults and in children.

Over 1,200 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes - more than in any other pathophysiology text. A fully updated glossary includes 1,000 terms, and makes lookup easier by grouping together similar topics and terms. Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition. Chapter summary reviews provide concise synopses of the main points of each chapter. Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment. Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content. Algorithms and flowcharts of diseases and disorders make it easy to follow the sequential progression of disease processes. Nutrition and Disease boxes explain the link between concepts of health promotion and disease. EXTENSIVELY Updated content reflects advances in pathophysiology including tumor biology invasion and metastases, the epidemiology of cancer, diabetes mellitus, insulin resistance, thyroid and adrenal gland disorders, female reproductive disorders including benign breast diseases and breast cancer, and a separate chapter on male reproductive disorders and cancer. NEW! Chapter on epigenetics and disease. Additional What's New boxes highlight the most current research and clinical development.

Tabla de contenidos provista por Syndetics

• Introduction to Pathophysiology
• Part 1 Central Concepts Of Pathophysiology: Cells And Tissues
• Unit I The Cell
• Cellular Biology
• Altered Cellular and Tissue Biology
• The Cellular Environment: Fluids and Electrolytes, Acids and Bases
• Unit II Genes and Gene-Environment Interaction
• Genes and Genetic Diseases
• Genes, Environment, Life-style, and Common Diseases
• Unit III Mechanisms of Self-Defense
• Innate Immunity: Inflammation
• Adaptive Immunity
• Alterations in Immunity and Inflammation
• Infection
• Stress and Disease
• Unit IV Cellular Proliferation: Cancer
• Biology, Clinical Manifestations, and Treatment of Cancer
• Cancer Epidemiology
• Cancer in Children
• Part 2 Pathophysiologic Alterations: Organs And Systems
• Unit V The Neurologic System
• Structure and Function of the Neurologic System
• Pain, Temperature Regulation, Sleep, and Sensory Function
• Alterations in Cognitive Systems, Cerebral Hemodynamics and Motor Function
• Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction
• Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders
• Alterations of Neurologic Function in Children
• Unit VI The Endocrine System
• Mechanisms of Hormonal Regulation
• Alterations of Hormonal Regulation
• Unit VII The Reproductive Systems
• Structure and Function of the Reproductive Systems
• Alterations of the Reproductive Systems
• Sexually Transmitted Infections
• Unit VIII The Hematologic System
• Structure and Function of the Hematologic System
• Alterations of Erythrocyte Function
• Alterations of Leukocyte, Lymphoid, and Hemostatic Function
• Alterations of Hematologic Function in Children
• Unit IX The Cardiovascular and Lymphatic Systems
• Structure and Function of the Cardiovascular and Lymphatic Systems
• Alterations of Cardiovascular Function
• Alterations of Cardiovascular Function in Children
• Unit X The Pulmonary System
• Structure and Function of the Pulmonary System
• Alterations of Pulmonary Function
• Alterations of Pulmonary Function in Children
• Unit XI The Renal and Urologic System
• Structure and Function of the Renal and Urologic Systems
• Alterations of Renal and Urinary Tract Function
• Alterations of Renal and Urinary Tract Function in Children
• Unit XII The Digestive System
• Structure and Function of the Digestive System
• Alterations of Digestive Function
• Alterations of Digestive Function in Children
• Unit XIII The Musculoskeletal System
• Structure and Function of the Musculoskeletal System
• Alterations of Musculoskeletal Function
• Alterations of Musculoskeletal Function in Children
• Unit XIV The Integumentary System
• Structure, Function, and Disorders of the Integument
• Alterations of the Integument in Children
• Unit XV Multiple Interacting Systems
• Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults
• Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children