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Tabla de contenidos provista por Syndetics

• Preface
• 1 The AIDS Epidemic(p. 2)
• Looking Ahead(p. 2)
• Introduction(p. 2)
• The Early Years(p. 2)
• The First Observations(p. 3)
• The Breakthrough(p. 8)
• Another AIDS Virus(p. 10)
• A Pandemic(p. 12)
• Origin of the AIDS Epidemic(p. 13)
• The Origin of HIV(p. 14)
• The Jump to Humans(p. 16)
• Out of Africa(p. 18)
• Entry into the United States(p. 19)
• The First Decades and Beyond(p. 21)
• Two Decades of AIDS(p. 21)
• AIDS in the Twenty-First Century(p. 24)
• Looking Back(p. 25)
• 2 Viruses and HIV(p. 30)
• Looking Ahead(p. 30)
• Introduction(p. 30)
• Structure of Viruses and HIV(p. 31)
• Replication of Viruses and HIV(p. 36)
• Adsorption(p. 37)
• Penetration and Infection(p. 40)
• Lysogeny of HIV(p. 42)
• HIV Activation and Release(p. 44)
• Cell Destruction(p. 45)
• The HIV Genome(p. 48)
• Nine Genes(p. 48)
• Three Groups of HIV(p. 50)
• Inhibiting Viruses(p. 51)
• Looking Back(p. 53)
• 3 The Immune System and HIV(p. 58)
• Looking Ahead(p. 58)
• Introduction(p. 58)
• Development of the Immune System(p. 60)
• Antigens(p. 64)
• The Immune Process(p. 65)
• Cell-Mediated Immunity(p. 65)
• Antibody-Mediated Immunity(p. 68)
• HIV and the Immune System(p. 71)
• The Focus of HIV(p. 74)
• The Effects of HIV(p. 77)
• Looking Back(p. 80)
• 4 Defining and Recognizing AIDS(p. 84)
• Looking Ahead(p. 84)
• Introduction(p. 84)
• The Case Definition(p. 85)
• HIV Infection(p. 86)
• AIDS-Related Complex(p. 90)
• Acquired Immune Deficiency Syndrome(p. 94)
• The CDC Stages of Disease(p. 95)
• The Walter Reed Classification System(p. 97)
• HIV Wasting Syndrome(p. 98)
• AIDS-Dementia Complex(p. 98)
• Kaposi's Sarcoma(p. 100)
• Opportunistic Diseases(p. 103)
• Pediatric AIDS(p. 108)
• Looking Back(p. 111)
• 5 The Epidemiology of AIDS(p. 114)
• Looking Ahead(p. 114)
• Introduction(p. 114)
• AIDS and the Epidemiologist(p. 115)
• The Spreading Epidemic(p. 117)
• The Fragility of HIV(p. 120)
• AIDS in Homosexual Men(p. 121)
• AIDS in Injection Drug Users(p. 124)
• AIDS in Heterosexuals(p. 125)
• AIDS in Women(p. 128)
• AIDS in Newborns(p. 130)
• AIDS in Africa(p. 135)
• AIDS in the World(p. 138)
• Other Transmission Methods(p. 141)
• How AIDS Is Not Transmitted(p. 142)
• Improbable Transmission(p. 142)
• The Mosquito Connection(p. 144)
• AIDS in Schools and Colleges(p. 144)
• Looking Back(p. 147)
• 6 Preventing HIV Transmission(p. 152)
• Looking Ahead(p. 152)
• Introduction(p. 152)
• Personal Protection(p. 153)
• Safer Sex Practices(p. 155)
• For Injection Drug Users(p. 159)
• Protecting Health Care Workers(p. 162)
• Universal Precautions(p. 163)
• Invasive Procedures(p. 164)
• Dentistry(p. 165)
• Autopsy and Embalming(p. 166)
• Medical Laboratories(p. 167)
• Decontamination Procedures(p. 168)
• Exposures to HIV(p. 169)
• Protecting Public Safety Workers(p. 172)
• Fire and Emergency Medical Services(p. 173)
• Law Enforcement Officers(p. 175)
• AIDS Education in the Schools(p. 177)
• Looking Back(p. 179)
• 7 HIV Testing and Diagnosis(p. 184)
• Looking Ahead(p. 184)
• Introduction(p. 184)
• HIV Antibody Tests(p. 185)
• Enzyme-Linked Immunosorbent Assay (ELISA)(p. 186)
• Western Blot Analysis(p. 188)
• False Positives and Negatives(p. 191)
• Other Antibody Tests(p. 193)
• Home and Simplified Tests(p. 194)
• HIV Antigen (Viral Load) Tests(p. 195)
• Gene Probes(p. 196)
• The Polymerase Chain Reaction(p. 197)
• Advantages of the Viral Load Test(p. 200)
• Protein and T-Lymphocyte Tests(p. 202)
• Implications of HIV Testing(p. 202)
• Mandatory Testing(p. 204)
• Voluntary Testing(p. 205)
• Looking Back(p. 207)
• 8 Treating HIV Infection and AIDS(p. 212)
• Looking Ahead(p. 212)
• Introduction(p. 213)
• General Principles of AIDS Treatment(p. 214)
• Objectives of Therapeutic Drugs(p. 214)
• Approaches to Drug Therapy(p. 216)
• Mutations and Other Considerations(p. 218)
• Reverse Transcriptase Inhibitors(p. 220)
• Azidothymidine (AZT)(p. 223)
• Other Dideoxynucleosides(p. 227)
• Nonnucleoside Analogs(p. 229)
• Other Therapeutic Agents(p. 230)
• Protease Inhibitors(p. 230)
• Fusion Inhibitors(p. 233)
• Entry Inhibitors(p. 237)
• Interleukin-2(p. 238)
• Antisense Molecules(p. 239)
• Miscellaneous Therapeutic Agents(p. 240)
• Postexposure Prophylaxis(p. 243)
• Treating Opportunistic Diseases(p. 245)
• Pentamidine Isethionate(p. 245)
• Other Drugs(p. 246)
• Drug Development and Testing(p. 247)
• Drug Trials(p. 248)
• Key Questions about Drug Testing(p. 251)
• Alternative Therapies(p. 251)
• Bone Marrow Transplants(p. 252)
• Gene Therapy(p. 253)
• Thinking Well(p. 254)
• Looking Back(p. 255)
• 9 An AIDS Vaccine(p. 260)
• Looking Ahead(p. 260)
• Introduction(p. 260)
• General Vaccine Strategies(p. 262)
• Types of Vaccine(p. 263)
• AIDS Vaccine Strategies(p. 265)
• Sterilizing and Therapeutic Vaccines(p. 266)
• AIDS Subunit Vaccines(p. 267)
• Viable-Vector Vaccines(p. 271)
• A Whole-Virus Vaccine(p. 272)
• DNA Vaccines(p. 274)
• Problems in Vaccine Development(p. 275)
• Complexity of HIV(p. 275)
• Economic Issues(p. 276)
• Lack of Animal Models(p. 277)
• Vaccine Trials(p. 279)
• Issues to Consider(p. 280)
• The Race to Vaccine(p. 282)
• Looking Back(p. 283)
• 10 AIDS in Perspective(p. 288)
• Looking Ahead(p. 288)
• Introduction(p. 288)
• AIDS and Society(p. 289)
• AIDS in the Workplace(p. 292)
• Legal Issues(p. 295)
• Economic Issues(p. 298)
• AIDS and Medical Professionals(p. 303)
• Caring for the AIDS Patient(p. 305)
• Education and Terminology(p. 306)
• Home Care(p. 306)
• The Future of AIDS(p. 307)
• The Complexity of AIDS(p. 308)
• The Lessons of AIDS(p. 310)
• Looking Back(p. 311)
• Appendix A Answers to Review Questions(p. 316)
• Appendix B A Suggested Format for a 10-Session Course: The Biological Basis of AIDS(p. 317)
• Pronunciation Guide(p. 319)
• Glossary(p. 321)
• Index(p. 328)