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This is a holistic, evidence-based approach to practicing psychotherapy for both the experienced and neophyte advanced practice nurse. Integrating neuroscience with psychotherapeutic theory, this award-winning text presents clear, step-by-step guidelines for techniques that reflect the wealth of experience garnered by Dr. Wheeler, an APN clinician of many years. The book unites disparate psychotherapeutic approaches into a model that is concise and straightforward, yet sufficiently comprehensive to provide a framework for practice that highlights the most useful models, principles, and techniques of psychotherapy. This second edition expands Peplau's interpersonal paradigm, validated by neuroscience and attachment research, from a two-person model to a more contemporary holistic perspective. It presents a practice framework that is based on relationship science and Adaptive Information Processing as an explanatory mechanism. The text educates APNs in the developmental and psychodynamic issues that are critical to accurate assessment and subsequent treatment. It also features several new chapters focusing on Motivational Interviewing, Integrating Complementary Modalities, Cognitive Processing Therapy for Trauma, EMDR, and Working with the Substance Abusing Client. The book features a hierarchical framework for treatment and is replete with case illustrations and practice examples. Also included are helpful communication techniques, assessment tools, and forms for practice.