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Principles of Genetics is one of the most popular texts in use for the introductory course. It opens a window on the rapidly advancing science of genetics by showing exactly how genetics is done. Throughout, the authors incorporate a human emphasis and highlight the role of geneticists to keep students interested and motivated. The sixth edition has been updated to reflect the latest developments in the field of genetics. Principles of Genetics continues to educate today's students for tomorrow's science by focusing on features that aid in content comprehension and application.

Tabla de contenidos provista por Syndetics

• Chapter 1 The Science of Genetics(p. 1)
• An Invitation(p. 2)
• Three Great Milestones in Genetics(p. 2)
• DNA as the Genetic Material(p. 6)
• Genetics and Evolution(p. 10)
• Levels of Genetic Analysis(p. 11)
• Genetics in the World: Applications of Genetics to Human Endeavors(p. 12)
• Chapter 2 Cellular Reproduction(p. 18)
• Cells and Chromosomes(p. 19)
• Mitosis(p. 24)
• Meiosis(p. 27)
• Life Cycles of Some Model Genetic Organisms(p. 32)
• Chapter 3 Mendelism: The Basic Principles of Inheritance(p. 40)
• MendelâÇÖs Study of Heredity(p. 41)
• Applications of MendelâÇÖs Principles(p. 46)
• Testing Genetic Hypotheses(p. 48)
• Mendelian Principles in Human Genetics(p. 52)
• Chapter 4 Extensions of Mendelism(p. 62)
• Allelic Variation and Gene Function(p. 63)
• Gene Action: From Genotype to Phenotype(p. 70)
• Inbreeding: Another Look at Pedigrees(p. 77)
• Chapter 5 The Chromosomal Basis of Mendelism(p. 89)
• Chromosomes(p. 90)
• The Chromosome Theory of Heredity(p. 92)
• Sex-Linked Genes in Humans(p. 98)
• Sex Chromosomes and Sex(p. 98)
• Determination(p. 100)
• Dosage Compensation of X-Linked Genes(p. 104)
• Chapter 6 Variation in Chromosome Number and Structure(p. 110)
• Cytological Techniques(p. 111)
• Polyploidy(p. 115)
• Aneuploidy(p. 119)
• Rearrangements of Chromosome Structure(p. 126)
• Chapter 7 Linkage, Crossing Over, and Chromosome Mapping in Eukaryotes(p. 135)
• Linkage, Recombination, and Crossing Over(p. 136)
• Chromosome Mapping(p. 141)
• Cytogenetic Mapping(p. 148)
• Linkage Analysis in Humans(p. 150)
• Recombination and Evolution(p. 153)
• Chapter 8 The Genetics of Bacteria and Their Viruses(p. 163)
• Viruses and Bacteria in Genetics(p. 164)
• The Genetics of Viruses(p. 165)
• The Genetics of Bacteria(p. 169)
• Mechanisms of Genetic Exchange in Bacteria(p. 172)
• The Evolutionary Significance of Genetic Exchange in Bacteria(p. 186)
• Chapter 9 DNA and the Molecular Structure of Chromosomes(p. 192)
• Functions of the Genetic Material(p. 193)
• Proof That Genetic Information Is Stored in DNA(p. 193)
• The Structures of DNA and RNA(p. 197)
• Chromosome Structure in Prokaryotes and Viruses(p. 205)
• Chromosome Structure in Eukaryotes(p. 207)
• Chapter 10 Replication of DNA and Chromosomes(p. 220)
• Basic Features of DNA Replication In Vivo(p. 221)
• DNA Replication in Prokaryotes(p. 231)
• Unique Aspects of Eukaryotic Chromosome Replication(p. 244)
• Chapter 11 Transcription and RNA Processing(p. 256)
• Transfer of Genetic Information: The Central Dogma(p. 257)
• The Process of Gene Expression(p. 259)
• Transcription in Prokaryotes(p. 263)
• Transcription and RNA Processing in Eukaryotes(p. 267)
• Interrupted Genes in Eukaryotes: Exons and Introns(p. 274)
• Removal of Intron Sequences by RNA Splicing(p. 277)
• Chapter 12 Translation and the Genetic Code(p. 285)
• Protein Structure(p. 286)
• One Gene--One Colinear Polypeptide(p. 289)
• Protein Synthesis: Translation(p. 293)
• The Genetic Code(p. 306)
• Codon-tRNA Interactions(p. 312)
• Chapter 13 Mutation, DNA Repair, and Recombination(p. 320)
• Mutation: Source of the Genetic Variability Required for Evolution(p. 321)
• The Molecular Basis of Mutation(p. 321)
• Mutation: Basic Features of the Process(p. 332)
• Mutation: Phenotypic Effects(p. 337)
• Assigning Mutations to Genes by the Complementation Test(p. 342)
• Screening Chemicals for Mutagenicity: The Ames Test(p. 346)
• DNA Repair Mechanisms(p. 348)
• Inherited Human Diseases with Defects in DNA Repair(p. 351)
• DNA Recombination Mechanisms(p. 354)
• Chapter 14 The Techniques of Molecular Genetics(p. 366)
• Basic Techniques Used to Identify, Amplify, and Clone Genes(p. 367)
• Construction and Screening of DNA Libraries(p. 377)
• The Molecular Analysis of DNA, RNA, and Protein(p. 380)
• The Molecular Analysis of Genes and Chromosomes(p. 386)
• Chapter 15 Genomics(p. 397)
• Genomics: An Overview(p. 402)
• Correlated Genetic, Cytological, and Physical Maps of Chromosomes(p. 402)
• Map Position-Based Cloning of Genes(p. 407)
• The Human Genome Project(p. 409)
• RNA and Protein Assays of Genome Function(p. 415)
• Comparative Genomics(p. 420)
• Chapter 16 Applications of Molecular Genetics(p. 439)
• Use of Recombinant DNA Technology to Identify Human Genes and Diagnose Human Diseases(p. 440)
• Molecular Diagnosis of Human Diseases(p. 448)
• Human Gene Therapy(p. 450)
• DNA Profiling(p. 455)
• Production of Eukaryotic Proteins in Bacteria(p. 461)
• Transgenic Plants and Animals(p. 463)
• Reverse Genetics: Dissecting Biological Processes by Inhibiting Gene Expression(p. 467)
• Chapter 17 Transposable Genetic Elements(p. 477)
• Transposable Elements: An Overview(p. 478)
• Transposable Elements in Bacteria(p. 479)
• Cut-and-Paste Transposons in Eukaryotes(p. 483)
• Retroviruses and Retrotransposons(p. 488)
• Transposable Elements in Humans(p. 494)
• The Genetic and Evolutionary Significance of Transposable Elements(p. 496)
• Chapter 18 Regulation of Gene Expression in Prokaryotes(p. 504)
• Constitutive, Inducible, and Repressible Gene Expression(p. 506)
• Positive and Negative Control of Gene Expression(p. 507)
• Operons: Coordinately Regulated Units of Gene Expression(p. 509)
• The Lactose Operon in E. coli: Induction and Catabolite Repression(p. 511)
• The Tryptophan Operon in E. coli: Repression and Attenuation(p. 519)
• Translational Control of Gene Expression(p. 525)
• Posttranslational Regulatory Mechanisms(p. 526)
• Chapter 19 Regulation of Gene Expression in Eukaryotes(p. 531)
• Ways of Regulating Eukaryotic Gene Expression: An Overview(p. 532)
• Induction of Transcriptional Activity by Environmental and Biological Factors(p. 534)
• Molecular Control of Transcription in Eukaryotes(p. 537)
• Posttranscriptional Regulation of Gene Expression by RNA Interference(p. 541)
• Gene Expression and Chromatin Organization(p. 544)
• Activation and Inactivation of Whole Chromosomes(p. 550)
• Chapter 20 The Genetic Control of Animal Development(p. 558)
• A Genetic Perspective on Development(p. 559)
• Maternal Gene Activity in Development(p. 561)
• Genetic Analysis of Development in Vertebrates(p. 571)
• Chapter 21 The Genetic Basis of Cancer(p. 581)
• Cancer: A Genetic Disease(p. 582)
• Oncogenes(p. 585)
• Tumor Suppressor Genes(p. 590)
• Genetic Pathways to Cancer(p. 600)
• Chapter 22 Inheritance of Complex Traits(p. 607)
• Complex Traits(p. 608)
• Statistics of Quantitative Genetics(p. 611)
• Analysis of Quantitative Traits(p. 613)
• Correlations Between Relatives(p. 624)
• Quantitative Genetics of Human Behavioral Traits(p. 628)
• Chapter 23 Population Genetics(p. 634)
• The Theory of Allele Frequencies(p. 635)
• Natural Selection(p. 641)
• Random Genetic Drift(p. 645)
• Populations in Genetic Equilibrium(p. 647)
• Chapter 24 Evolutionary Genetics(p. 656)
• The Emergence of Evolutionary Theory(p. 657)
• Genetic Variation in Natural Populations(p. 659)
• Molecular Evolution(p. 662)
• Speciation(p. 672)
• Human Evolution(p. 676)
• Appendices
• Appendix A The Rules of Probability(p. 685)
• Appendix B Binomial Probabilities(p. 687)
• Appendix C In Situ Hybridization(p. 689)
• Appendix D Evidence for an Unstable Messenger RNA(p. 691)
• Appendix E Evolutionary Rates(p. 693)
• Answers to Odd-Numbered Questions and Problems(p. 697)
• Glossary(p. 720)
• Photo Credits(p. 743)
• Illustration Credits(p. 745)
• Index(p. 746)

Notas de autor provistas por Syndetics

D. Peter Snustad is a Professor Emeritus at the University of Minnesota, Twin Cities. He received his B.S. degree from the University of Minnesota and his M.S. and Ph.D. degrees from the University of California, Davis. He began his faculty career in the Department of Agronomy and Plant Genetics at Minnesota in 1965, became a charter member of the new Department of Genetics in 1966, and moved to the Department of Plant Biology in 2000. During his 43 years at Minnesota, he taught courses ranging from general biology to biochemical genetics. His initial research focused on the interactions between bacteriophage T4 and its host, E. coli. In the 1980s, his research switched to the cytoskeleton of Arabidopsis and the glutamine synthetase genes of corn. His honors include the Morse-Amoco and Dagley Memorial teaching awards and election to Fellow of the American Association for the Advancement of Science. A lifelong love of the Canadian wilderness has kept him in nearby Minnesota.

Michael J. Simmons is a Professor in the Department of Genetics, Cell Biology and Development at the University of Minnesota, Twin Cities. He received his B.A. degree in biology from St. Vincent College in Latrobe, Pennsylvania, and his M.S. and Ph.D. degrees in genetics from the University of Wisconsin, Madison. Dr. Simmons has taught a variety of courses, including genetics and population genetics. He has also mentored many students on research projects in his laboratory. Early in his career he received the Morse-Amoco teaching award from the University of Minnesota in recognition of his contributions to undergraduate education. Dr. Simmons's research focuses on the genetic significance of transposable elements in the genome of Drosophila melanogaster . He has served on advisory committees at the National Institutes of Health and was a member of the Editorial Board of the journal Genetics for 21 years. One of his favorite activities, figure skating, is especially compatible with the Minnesota climate.