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The sixth edition of this best-selling textbook presents a systematic account of the effects, both good and bad, of the immune system. Special emphasis is placed on what the immune system actually does in causing and preventing disease. Divided into two parts, the sixth edition discusses inflammation, the fundamentals of the immune system and how it is activated, the seven immune effector mechanisms, and how these effector mechanisms act not only to protect against infection and cancer but also to cause diseases. Valuable reading for physicians, medical students, graduate students, nurse practitioners, physician assistants, teachers of immunology, and advanced courses in immunology.

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• Preface(p. xix)
• I Immunology(p. 1)
• 1 Introduction to Part I(p. 3)
• Immunity(p. 3)
• The Inflammatory Response(p. 6)
• Immunopathology (the Double-Edged Sword)(p. 8)
• Summary(p. 8)
• Bibliography(p. 9)
• 2 Cells of the Immune System(p. 10)
• The Blood and Lymphoid Systems(p. 10)
• Blood Cells(p. 10)
• Cellular Interactions in Immune Responses(p. 24)
• Hematopoiesis (Blood Formation)(p. 25)
• Summary(p. 30)
• Bibliography(p. 30)
• 3 Inflammation and Wound Healing(p. 33)
• The Inflammatory Process(p. 33)
• Acute Inflammation(p. 35)
• The Cells of Acute Inflammation(p. 38)
• Serum Protein Systems(p. 54)
• Adult Respiratory Distress Syndrome(p. 69)
• Interrelationships of Inflammatory Cells and Protein Systems in Acute Inflammation(p. 69)
• Chronic Inflammation(p. 71)
• The Cells of Chronic Inflammation(p. 71)
• Cytokines in Chronic Inflammation(p. 77)
• Chemokines(p. 80)
• Apoptosis(p. 83)
• Wound Healing(p. 85)
• Review of Mediators of Inflammation(p. 88)
• Manifestations of Inflammation in Tissues(p. 89)
• Cytokines, Adhesion Molecules, and Growth Factors in Atherosclerosis(p. 90)
• Amyloidosis(p. 91)
• Alzheimer's Disease(p. 95)
• Summary(p. 96)
• Bibliography(p. 96)
• 4 All about B Cells(p. 101)
• B Cells and Antibodies(p. 101)
• Antibodies(p. 101)
• Immunoglobulin Structure(p. 105)
• Antibody-Antigen Reactions(p. 117)
• The B-Cell Receptor (BCR)(p. 129)
• Immunoglobulin Genes(p. 131)
• B-Cell Development(p. 142)
• Gene Rearrangements in Lymphomas and Leukemias(p. 144)
• Application of Antibody Technology to Therapy(p. 145)
• Summary(p. 147)
• Bibliography(p. 147)
• 5 All about T Cells and Induction of Immunity(p. 150)
• T Cells and the Immune Response(p. 150)
• The T-Cell Receptor(p. 156)
• T-Cell Activation(p. 159)
• The Major Histocompatibility Complex(p. 170)
• T-Cell-B-Cell Interactions, the MHC, and the Immune Response(p. 174)
• Prophylactic Immunization (Vaccination)(p. 180)
• Summary(p. 191)
• Bibliography(p. 193)
• 6 Lymphoid Organs(p. 198)
• The Lymphatic System: Vessels and Organs(p. 198)
• Lymphoid Organs: Structure and Function(p. 201)
• Development of Lymphoid Organs (Ontogeny)(p. 225)
• Summary(p. 227)
• Bibliography(p. 227)
• II Immunopathology and Immunity(p. 233)
• 7 Introduction to Part II(p. 235)
• Immunity, Immunopathology, Hypersensitivity, and Allergy(p. 235)
• Immune Effector Mechanisms(p. 236)
• The "Double-Edged Sword" of Immune Defense Mechanisms(p. 238)
• Bibliography(p. 239)
• 8 Inactivation and Activation of Biologically Active Molecules(p. 240)
• Mechanisms of Antibody-Mediated Inactivation and Activation(p. 240)
• Examples of Antibody-Mediated Inactivation and Activation(p. 244)
• Ligands, Receptors, and Idiotypes(p. 260)
• Neutralizing Antibodies: Cause and Effect(p. 261)
• Protective Functions of Inactivating (Neutralizing) Antibodies(p. 262)
• Summary(p. 270)
• Bibliography(p. 270)
• 9 Cytotoxic and Cytolytic Reactions(p. 276)
• The Mechanism of Cytolytic Reactions(p. 276)
• Immunohematologic Diseases(p. 278)
• Cytolytic Skin Diseases(p. 291)
• Other Cytotoxic Reactions(p. 291)
• Detection of Circulating Cytotoxic Antibodies(p. 292)
• Protective and Pathologic Effects in Infectious Diseases(p. 293)
• Summary(p. 299)
• Bibliography(p. 299)
• 10 Immune Complex Reactions(p. 302)
• Immune Complexes In Vivo(p. 302)
• The Arthus Reaction(p. 302)
• Serum Sickness(p. 304)
• Immune Complexes in Infectious Diseases(p. 307)
• Glomerulonephritis(p. 308)
• Vasculitis(p. 318)
• Rheumatic Fever(p. 323)
• Diffuse Connective Tissue Diseases(p. 325)
• Other Immune Complex Diseases(p. 352)
• Evaluation of Circulating Immune Complexes(p. 353)
• Summary(p. 353)
• Bibliography(p. 353)
• 11 Atopic and Anaphylactic Reactions (Allergy)(p. 359)
• Introduction(p. 359)
• Allergens(p. 362)
• Reaginic Antibody(p. 363)
• Anaphylaxis(p. 367)
• Atopic Allergy(p. 369)
• Asthma(p. 370)
• Atopic Reactions(p. 375)
• Urticaria and Angioedema(p. 380)
• Immunotherapeutic Modification of Atopic Allergy(p. 383)
• Pharmacologic Control of Atopic Reactions(p. 387)
• Treatment of Allergies(p. 391)
• Summary(p. 394)
• Bibliography(p. 395)
• 12 T-Cell-Mediated Cytotoxicity(p. 401)
• Cell-Mediated Immunity(p. 401)
• T[subscript CTL], T[subscript DTH], and Natural Killer Cells(p. 401)
• Induction of T-Cell Immunity(p. 404)
• T[subscript CTL]-Cell Reactions in Vitro(p. 405)
• T[subscript CTL]-Cell Reactions in Vivo(p. 406)
• Summary(p. 427)
• Bibliography(p. 427)
• 13 Delayed-Type Hypersensitivity(p. 431)
• T[subscript DTH]-Cell Reactions: Delayed-Type Hypersensitivity(p. 431)
• T[subscript DTH]-Cell Activation and Superantigens(p. 432)
• Delayed-Type Hypersensitivity Skin Reaction(p. 434)
• Cutaneous Basophil Hypersensitivity(p. 436)
• Transfer Factor(p. 436)
• Delayed-Type Hypersensitivity and Infection(p. 437)
• T[subscript DTH]-Cell-Mediated Autoimmune Disease(p. 439)
• Viral Encephalitis(p. 443)
• T[subscript CTL] and T[subscript DTH] Cells, Tuberculosis, and Leprosy(p. 447)
• Summary(p. 448)
• Bibliography(p. 448)
• 14 Granulomatous Reactions(p. 452)
• The Nature of Granulomas(p. 452)
• Granulomatous Diseases(p. 455)
• Summary(p. 473)
• Bibliography(p. 473)
• 15 Interplay of Inflammatory and Immunopathologic Mechanisms, Immune Defense, and Evasion of Immune Defense Mechanisms during Infection(p. 478)
• Nonimmune Inflammation(p. 478)
• Immune Inflammation(p. 478)
• Interaction of Immune and Nonimmune Inflammation(p. 481)
• Immune-Specific Protection against Infection(p. 481)
• Interaction of Immune Mechanisms in Some Infectious Diseases(p. 488)
• Evasion of Immune Defense Mechanisms(p. 492)
• Summary(p. 505)
• Bibliography(p. 507)
• 16 Immune-Mediated Skin Diseases(p. 510)
• The Skin Immune System(p. 510)
• Inactivation or Activation(p. 513)
• Cytotoxic or Cytolytic Reactions(p. 515)
• Immune Complex Reactions(p. 517)
• Anaphylactic Reactions(p. 518)
• Cell-Mediated Reactions(p. 520)
• Granulomatous Lesions(p. 523)
• Disorders of Coagulation(p. 524)
• Summary(p. 524)
• Bibliography(p. 524)
• 17 Immunoproliferative Diseases(p. 528)
• Leukemias and Lymphomas(p. 528)
• Maturation of Blood-Forming Cells and Leukemia(p. 529)
• Lymphoid Tissue Structure and Lymphoproliferative Disease(p. 529)
• Nonmalignant Lymphoproliferation(p. 529)
• Malignant Lymphomas(p. 532)
• Infections Associated with Lymphoproliferative Diseases(p. 551)
• Summary(p. 551)
• Bibliography(p. 552)
• 18 Immunodeficiency Diseases(p. 556)
• Immune Deficiencies and Infections(p. 556)
• Primary Immunodeficiencies(p. 558)
• Secondary Immunodeficiencies(p. 573)
• Opportunistic Infections(p. 577)
• Evaluation of Immunodeficiency(p. 578)
• Therapy(p. 579)
• Summary(p. 586)
• Bibliography(p. 587)
• 19 Immunology of AIDS(p. 590)
• Human Immunodeficiency Virus(p. 590)
• AIDS(p. 598)
• Summary(p. 621)
• Bibliography(p. 623)
• 20 Tumor Immunity(p. 628)
• History of Tumor Immunity(p. 628)
• Evidence for Tumor Immunity in Humans(p. 628)
• Carcinogenesis and Tumor Immunity(p. 631)
• Types of Tumor Antigens(p. 632)
• Mechanisms of Tumor Cell Destruction by the Immune System(p. 638)
• Immunosurveillance(p. 642)
• Immunodiagnosis of Cancer(p. 647)
• Immunotherapy of Cancer(p. 662)
• Summary(p. 676)
• Bibliography(p. 676)
• Appendix 1 History of Immunopathology(p. 685)
• Appendix 2 Evolution of Immunity (Phylogeny)(p. 691)
• Appendix 3 Cluster-of-Differentiation Molecules(p. 697)
• Appendix 4 Cytokines(p. 717)
• Appendix 5 Clinical Immunology Tests(p. 721)
• Appendix 6 Tables of Lymphoproliferative Diseases(p. 727)
• Index(p. 731)