Descripciones mejoradas de Syndetics:

The use of biocatalysts, employed either as isolated enzymes or whole cells, offers a remarkable arsenal of highly selective transformations for modern preparative organic chemistry. During the last decade, this methodology has now generally been accepted as a complementary method to the already existing tools. This first textbook on biocatalysis provides a basis for undergraduate & graduate courses in biocatalysis, as well as a condensed introduction into this field. After a basic introduction into the use of biocatalysts - principles of stereoselective transformations, kinetics, enzyme nomenclature & handling - the different types of reactions are explained according to the "reaction principle." The 4th edition includes new chapters on peroxidase reactions & on handling of biocatalysts.

Tabla de contenidos provista por Syndetics

• Preface
• 1 Introduction and Background Information
• 1.1 Introduction(p. 1)
• 1.2 Common Prejudices Against Enzymes(p. 1)
• 1.3 Advantages and Disadvantages of Biocatalysts(p. 3)
• 1.3.1 Advantages of Biocatalysts(p. 3)
• 1.3.2 Disadvantages of Biocatalysts(p. 7)
• 1.3.3 Isolated Enzvmcs versus Whole Cell Svstems(p. 9)
• 1.1 Enzyme Properties and Nomenclature(p. 11)
• 1.4.1 Mechanistic Aspects(p. 12)
• 1.4.2 Classification and Nomenclature(p. 21)
• 1.4.3 Coenzymes(p. 24)
• 1.4.4 Hnzyme Sources(p. 25)
• References|26
• 12 Biocatalytic Applications
• 2.1 Hvdrolvtic Reactions(p. 29)
• 2.1.1 Mechanistic and Kinetic Aspects(p. 29)
• 2.1.2 Hvdrolvsis of the Amide Bond(p. 52)
• 2.1.3 Ester Hydrolysis(p. 63)
• 2.1.3.1 Esterases and Proteases(p. 63)
• 2.1.3.2 Lipases(p. 94)
• 2.1.4 Hydrolysis and Formation of Phosphate Esters(p. 123)
• 2.1.5 Hydrolysis of Epoxides(p. 135)
• 2.1.6 Hydrolysis of Nitriles(p. 149)
• References(p. 159)
• 2.2 Reduction Reactions1(p. 77)
• 2.2.1 Recycling of Cofaclors(p. 177)
• 2.2.2 Reduction of Aldehydes and Kelones Using Isolated Enzymes(p. 184)
• 2.2.3 Reduction of Aldehydes and Ketones Using Whole Cells(p. 192)
• 2.2.4 Reduction of C=C-Bonds Using Whole Cells(p. 206)
• References(p. 213)
• 2.3 Oxidation Reactions(p. 220)
• 2.3.1 Oxidation of Alcohols and Aldehydes(p. 220)
• 2.3.2 Oxygenation Reactions(p. 225)
• 2.3.2.1 Hydroxylatiou of Alkanes(p. 230)
• 2.3.2.2 Hydroxylatiou of Aromatic Compounds(p. 234)
• 2.3.2.3 Epoxidation of Alkenes(p. 236)
• 2.3.2.4 Sulfoxidation Reactions(p. 240)
• 2.3.2.5 Baeyer-Viliiger Reactions(p. 242)
• 2.3.2.6 Formation of Peroxides(p. 249)
• 2.3.2.7 Dihydroxylation of Aromatic Compounds(p. 253)
• 2.3.3 Peroxidation Reactions(p. 256)
• References(p. 264)
• 2.4 Formation of Carbon-Caxbon Bonds(p. 273)
• 2.4.1 Aldol-Reactions(p. 273)
• 2.4.2 Acyloin-Reactious(p. 289)
• 2.4.3 Michael-Type Additions(p. 292)
• References(p. 294)
• 2.5 Addition and Elimination Reactions(p. 298)
• 2.5.1 Cyanohydrin Formation(p. 298)
• 2.5.2 Addition of Water and Ammonia(p. 302)
• References(p. 305)
• 2.6 Glycosyl-Transfcr Reactions(p. 307)
• 2.6.1 Glycosyl Transferases(p. 307)
• 2.6.2 Glycosidascs(p. 311)
• References(p. 319)
• 2.7 Haiogcnation and Dehalogeaalion Reactions(p. 322)
• 2.7.1 Halogenation(p. 322)
• 2.7.2 Dehalogenation(p. 327)
• References(p. 332)
• 3 Special Techniques
• 3.1 Enzymes in Organic Solvents(p. 334)
• 3.1.1 Ester Synthesis(p. 344)
• 3.1.2 Lactone Synthesis(p. 366)
• 3.1.3 Amide Synthesis(p. 367)
• 3.1.4 Peptidc Synthesis(p. 370)
• 3.1.5 Peracid Synthesis(p. 377)
• 3.1.6 Redox Reactions(p. 378)
• 3.1.7 Medium Engineering(p. 381)
• 3.2 Immobilization(p. 384)
• 3.3 Modified and Artificial Enzymes(p. 397)
• 3.3.1 Modified Enzymes(p. 397)
• 3.3.2 Semisynthetic Enzymes(p. 401)
• 3.3.3 Catalytic Antibodies(p. 403)
• References(p. 408)
• 4 State of the Art and Outlook(p. 419)
• 5 Appendix
• 5.1 Basic Rules for Handling Biocatalysts(p. 425)
• 5.2 Abbreviations(p. 429)
• 5.3 Suppliers of Enzymes(p. 430)
• 5.4 Commonly Used Enzyme Preparations(p. 431)
• 5.5 Major Culture Collections(p. 434)
• 5.6 Pathogenic Bacteria and Fungi(p. 435)
• Subject Index(p. 436)