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Tabla de contenidos provista por Syndetics

• Preface(p. xiii)
• Chapter 1 Introduction to Molecular Genetics and Genomics(p. 1)
• 1.1 DNA: The Genetic Material(p. 2)
• 1.2 DNA Structure: The Double Helix(p. 9)
• 1.3 An Overview of DNA Replication(p. 10)
• 1.4 Genes and Proteins(p. 11)
• 1.5 Gene Expression: The Central Dogma(p. 16)
• 1.6 Mutation(p. 21)
• 1.7 Genes and Environment(p. 25)
• 1.8 Evolution: From Genes to Genomes, From Proteins to Proteomes(p. 27)
• Chapter End Material(p. 29)
• Chapter 2 DNA Structure and DNA Manipulation(p. 36)
• 2.1 Genomes and Genetic Differences Among Individuals(p. 39)
• 2.2 The Molecular Structure of DNA(p. 41)
• 2.3 The Separation and Identification of Genomic DNA Fragments(p. 49)
• 2.4 Selective Replication of Particular DNA Fragments(p. 58)
• 2.5 The Terminology of Genetic Analysis(p. 64)
• 2.6 Types of DNA Markers Present in Genomic DNA(p. 65)
• 2.7 Applications of DNA Markers(p. 73)
• Chapter End Material(p. 76)
• Chapter 3 Transmission Genetics: The Principle of Segregation(p. 86)
• 3.1 Morphological and Molecular Phenotypes(p. 88)
• 3.2 Segregation of a Single Gene(p. 90)
• 3.3 Segregation of Two or More Genes(p. 98)
• 3.4 Human Pedigree Analysis(p. 104)
• 3.5 Pedigrees and Probability(p. 107)
• 3.6 Incomplete Dominance and Epistasis(p. 111)
• 3.7 Genetic Analysis: Mutant Screens and the Complementation Test(p. 117)
• Chapter End Material(p. 123)
• Chapter 4 Genes and Chromosomes(p. 132)
• 4.1 The Stability of Chromosome Complements(p. 134)
• 4.2 Mitosis(p. 135)
• 4.3 Meiosis(p. 139)
• 4.4 Chromosomes and Heredity(p. 148)
• 4.5 Probability in the Prediction of Progeny Distributions(p. 158)
• 4.6 Testing Goodness of Fit to a Genetic Hypothesis(p. 161)
• 4.7 Are Mendel's Data Too Good to Be True?(p. 164)
• Chapter End Material(p. 166)
• Chapter 5 Genetic Linkage and Chromosome Mapping(p. 174)
• 5.1 Linkage and Recombination of Genes in a Chromosome(p. 176)
• 5.2 Genetic Mapping(p. 181)
• 5.3 Genetic Mapping in a Three-Point Testcross(p. 192)
• 5.4 Genetic Mapping in Human Pedigrees(p. 197)
• 5.5 Mapping by Tetrad Analysis(p. 201)
• 5.6 Recombination Within Genes(p. 209)
• 5.7 Mitotic Recombination(p. 209)
• Chapter End Material(p. 211)
• Chapter 6 Molecular Biology of DNA Replication and Recombination(p. 222)
• 6.1 Problems of Initiation, Elongation, and Incorporation Error(p. 224)
• 6.2 Semiconservative Replication of Double-Stranded DNA(p. 225)
• 6.3 Unwinding, Stabilization, and Stress Relief(p. 234)
• 6.4 Initiation by a Primosome Complex(p. 235)
• 6.5 Chain Elongation and Proofreading(p. 236)
• 6.6 Discontinuous Replication of the Lagging Strand(p. 238)
• 6.7 Terminator Sequencing of DNA(p. 242)
• 6.8 Molecular Mechanisms of Recombination(p. 248)
• Chapter End Material(p. 256)
• Chapter 7 Molecular Mechanisms of Mutation and DNA Repair(p. 264)
• 7.1 Types of Mutations(p. 266)
• 7.2 The Molecular Basis of Mutation(p. 268)
• 7.3 Transposable Elements(p. 274)
• 7.4 Spontaneous Mutation(p. 280)
• 7.5 Mutagens(p. 286)
• 7.6 Mechanisms of DNA Repair(p. 295)
• 7.7 Reverse Mutations and Suppressor Mutations(p. 300)
• Chapter End Material(p. 303)
• Chapter 8 Molecular Organization of Chromosomes(p. 310)
• 8.1 Genome Size and Evolutionary Complexity: The C-Value Paradox(p. 312)
• 8.2 The Supercoiling of DNA(p. 314)
• 8.3 The Structure of Bacterial Chromosomes(p. 316)
• 8.4 The Structure of Eukaryotic Chromosomes(p. 318)
• 8.5 Polytene Chromosomes(p. 323)
• 8.6 Repetitive Nucleotide Sequences in Eukaryotic Genomes(p. 324)
• 8.7 Unique and Repetitive Sequences in Eukaryotic Genomes(p. 329)
• 8.8 Centromere and Telomere Structure(p. 330)
• Chapter End Material(p. 338)
• Chapter 9 Human Karyotypes and Chromosome Behavior(p. 344)
• 9.1 The Human Karyotype(p. 346)
• 9.2 Chromosome Abnormalities in Spontaneous Abortion(p. 357)
• 9.3 Chromosomal Deletions and Duplications(p. 362)
• 9.4 Genetics of Chromosomal Inversions(p. 367)
• 9.5 Chromosomal Translocations(p. 370)
• 9.6 Genomic Position Effects on Gene Expression(p. 375)
• 9.7 Polyploidy in Plant Evolution(p. 377)
• 9.8 Genome Evolution in the Grass Family (Gramineae)(p. 382)
• Chapter End Material(p. 384)
• Chapter 10 Genetics of Bacteria and Their Viruses(p. 392)
• 10.1 Mobile DNA(p. 394)
• 10.2 Bacterial Genetics(p. 402)
• 10.3 DNA-Mediated Transformation(p. 403)
• 10.4 Conjugation(p. 405)
• 10.5 Transduction(p. 412)
• 10.6 Bacteriophage Genetics(p. 418)
• 10.7 Lysogeny and Specialized Transduction(p. 427)
• Chapter End Material(p. 435)
• Chapter 11 Molecular Biology of Gene Expression(p. 444)
• 11.1 Amino Acids, Polypeptides, and Proteins(p. 446)
• 11.2 Colinearity Between Coding Sequences and Polypeptides(p. 449)
• 11.3 Transcription(p. 452)
• 11.4 Messenger RNA(p. 456)
• 11.5 RNA Processing in Eukaryotes(p. 458)
• 11.6 Translation(p. 463)
• 11.7 Complex Translation Units(p. 468)
• 11.8 The Standard Genetic Code(p. 470)
• Chapter End Material(p. 482)
• Chapter 12 Molecular Mechanisms of Gene Regulation(p. 488)
• 12.1 Transcriptional Regulation in Prokaryotes(p. 490)
• 12.2 Lactose Metabolism and the Operon System of Gene Regulation(p. 492)
• 12.3 Regulation of the Tryptophan Operon(p. 499)
• 12.4 Regulation in Bacteriophage Lambda(p. 505)
• 12.5 Transcriptional Regulation in Eukaryotes(p. 507)
• 12.6 Epigenetic Mechanisms of Transcriptional Regulation(p. 518)
• 12.7 Regulation Through RNA Processing and Decay(p. 522)
• 12.8 Translational Control(p. 524)
• 12.9 Programmed DNA Rearrangements(p. 524)
• Chapter End Material(p. 532)
• Chapter 13 Genetic Engineering and Genomics(p. 540)
• 13.1 Restriction Enzymes and Vectors(p. 542)
• 13.2 Cloning Strategies(p. 546)
• 13.3 Detection of Recombinant Molecules(p. 551)
• 13.4 Transgenic Organisms(p. 556)
• 13.5 Site-Directed Mutagenesis and Knockout Mutations(p. 562)
• 13.6 Some Applications of Genetic Engineering(p. 564)
• 13.7 Analysis of Complex Genomes(p. 567)
• 13.8 Functional Genomics(p. 578)
• Chapter End Material(p. 581)
• Chapter 14 Genetic Control of Development(p. 590)
• 14.1 Genetic Determinants of Development(p. 592)
• 14.2 Early Embryonic Development in Animals(p. 594)
• 14.3 Genetic Analysis of Development in the Nematode(p. 598)
• 14.4 Genetic Control of Development in Drosophila(p. 607)
• 14.5 Genetic Control of Development in Higher Plants(p. 622)
• Chapter End Material(p. 626)
• Chapter 15 Molecular Genetics of the Cell Cycle and Cancer(p. 634)
• 15.1 The Cell Cycle(p. 636)
• 15.2 Genetic Analysis of the Cell Cycle(p. 640)
• 15.3 Progression Through the Cell Cycle(p. 642)
• 15.4 Checkpoints in the Cell Cycle(p. 648)
• 15.5 Cancer Cells(p. 655)
• 15.6 Hereditary Cancer Syndromes(p. 660)
• 15.7 Genetics of the Acute Leukemias(p. 666)
• Chapter End Material(p. 667)
• Chapter 16 Extranuclear Inheritance(p. 676)
• 16.1 Patterns of Extranuclear Inheritance(p. 678)
• 16.2 Organelle Heredity(p. 682)
• 16.3 The Evolutionary Origin of Organelles(p. 691)
• 16.4 Cytoplasmic Transmission of Symbionts(p. 691)
• 16.5 Maternal Effect in Snail Shell Coiling(p. 695)
• 16.6 In Search of Mitochondrial "Eve"(p. 696)
• Chapter End Material(p. 699)
• Chapter 17 Population Genetics and Evolution(p. 706)
• 17.1 Allele Frequencies and Genotype Frequencies(p. 708)
• 17.2 The Matter of Mating(p. 711)
• 17.3 Inbreeding(p. 722)
• 17.4 Genetics and Evolution(p. 727)
• 17.5 Mutation and Migration(p. 728)
• 17.6 Natural Selection(p. 730)
• 17.7 Random Genetic Drift(p. 736)
• Chapter End Material(p. 740)
• Chapter 18 The Genetic Basis of Complex Inheritance(p. 748)
• 18.1 Complex Traits(p. 750)
• 18.2 Causes of Variation(p. 754)
• 18.3 Genetic Analysis of Complex Traits(p. 760)
• 18.4 Artificial Selection(p. 763)
• 18.5 Correlation Between Relatives(p. 767)
• 18.6 Heritabilities of Threshold Traits(p. 770)
• 18.7 Identification of Genes Affecting Complex Traits(p. 772)
• Chapter End Material(p. 777)
• Answers to Even-Numbered Problems(p. 786)
• Concise Dictionary of Genetics(p. 804)
• Index(p. 834)