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The use of biocatalysts, employed either as isolated enzymes or whole cells, offers a remarkable arsenal of highly selective transformations for modern preparative organic chemistry. During the last decade, this methodology has now generally been accepted as a complementary method to the already existing tools. This first textbook on biocatalysis provides a basis for undergraduate and graduate courses in biocatalysis, as well as a condensed introduction into this field. After a basic introduction into the use of biocatalysts - principles of stereoselective transformations, kinetics, enzyme nomenclature and handling, the different types of reactions are explained according to the "reaction principle". Based on the success of the 2nd edition the educational character of the text has been further strengthened.

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• Common Prejudices Against Enzymes
• Advantages and Disadvantages of Biocatalysts
• Enzyme Properties and Nomenclature
• Hydrolytic Reactions
• Reduction Reactions
• Oxidation Reactions
• Formation of Carbon-Carbon Bonds
• Addition and Elimination Reactions
• Glycosyl-Transfer Reactions
• Halogenation and Dehalogenation Reactions
• Enzymes in Organic Solvents
• Immobilization
• Modified and Artificial Enzymes
• State of the Art and Outlook.

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CHOICE Review

Faber's 3rd edition (1st ed., 1992; 2nd ed., 1995) is interesting, timely, and significant, presenting a well-written introduction to the growing multidisciplinary approach to research. It is perhaps best suited for use in advanced courses, such as graduate work, or by persons at higher educational levels. It is not likely to be appropriate for the "typical undergraduate," although it might be a useful adjunct to directed undergraduate research and reading. This reviewer's sole criticism is that the book seems to oversimplify the relatively complex use and handling of enzymes. The inexperienced reader (assuming a strong organic chemistry background but relatively weak-to-nonexistent experience with biochemical samples and methods) might make some costly (in terms both of expense and time) errors en route to developing a useful protocol. For example, to a biochemist, "dilute acid" is about 0.1 M or less; to (some) organic chemists "dilute" may be 3 to 6 M! This reviewer strongly suggests that any experimental exploration be combined with consultation with experts or background reading. Graduate level. L. A. Andersson; Vassar College