Descripciones mejoradas de Syndetics:

On the cover of this book is a Pacific yew tree, found in the ancient forests of the Pacific Northwest. The bark of the Pacific yew tree produces Taxol, found to be a highly effective drug against ovarian and breast cancer. Taxol blocks mitosis during eukaryotic cell division. The supply of Taxol from the Pacific yew tree is vanishingly small, however. A single 100-year-old tree provides only about one dose of the drug (roughly 300 mg). For this reason, as well as the spectacular molecular architecture of Taxol, synthetic organic chemists fiercely undertook efforts to synthesize it. Five total syntheses of Taxol have thus far been reported. Now, a combination of isolation of a related metabolite from European yew needles, and synthesis of Taxol from that intermediate, supply the clinical demand. This case clearly demonstrates the importance of synthesis and the use of organic chemistry. It's just one of the many examples used in the text that will spark the interest of students and get them involved in the study of organic chemistry!

Tabla de contenidos provista por Syndetics

• 1 Carbon Compounds and Chemical Bonds
• 2 Representative Carbon Compounds: Functional Groups, Infrared Spectroscopy, & Intermolecular Force
• 3 An Introduction to Organic Reactions: Acids and Bases
• 4 Alkanes: Nomenclature, Conformational Analysis, & An Intro to Synthesis
• 5 Stereochemistry: Chiral Molecules
• 6 Ionic Reactions - Nucleophilic Substitution & Elimination Reactions: Alkyl Halides
• 7 Alkenes & Alkynes: Properties & Synthesis, Elimination Reactions of Alkyl Halides
• 8 Alkenes & Alkynes II: Addition Reaction
• 9 Spectroscopic Methods of Structure Determination
• 10 Radical Reactions
• 11 Alcohols & Ethers
• 12 Alcohols from Carbonyl Compounds, Oxidation-Reduction & Organometallic Compounds
• 13 Conjugated Unsaturated Systems
• 14 Aromatic Compounds
• 15 Reactions of Aromatic Compounds
• 16 Aldehydes & Ketones I: Nucleophilic Additions to the Carbonyl Group
• 17 Aldehydes & Ketones II: Enolates & Enols
• Aldol & Alkylation Reactions
• 18 Carboxylic Acids & Their Derivatives: Nucleophilic Substitution at the Acyl Carbon
• 19 Synthesis & Reactions of a-Dicarbonyl Compounds: More Chemistry of Enolate Ions
• 20 Amines
• 21 Phenols & Aryl Halides: Nucleophilic Aromatic Substitution
• 22 Carbohydrates
• 23 Lipids
• 24 Amino Acids & Proteins
• 25 Nucleic Acids & Protein Synthesis