Mechanistic toxicology
Boelsterli, Urs A.
Mechanistic toxicology the molecular basis of how chemicals disrupt biological targets Urs A. Boelsterli. - 2nd ed. - Boca Raton CRC Press c2007. - 399 p. ill. 25 cm.
Includes bibliographical references and index.
Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.
0849372720
2006035219
Molecular toxicology.
RA1220.3 / .B64 2007
615.9 / B6718m2
2007 F-245 QV 602 / B671n 2007
Mechanistic toxicology the molecular basis of how chemicals disrupt biological targets Urs A. Boelsterli. - 2nd ed. - Boca Raton CRC Press c2007. - 399 p. ill. 25 cm.
Includes bibliographical references and index.
Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.
0849372720
2006035219
Molecular toxicology.
RA1220.3 / .B64 2007
615.9 / B6718m2
2007 F-245 QV 602 / B671n 2007